X. Steven Chen

The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.

Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.

How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.

Assessed papers (1)

• Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection.
  2025 L1 78/100

1 assessed by us (1 reproduced) · 109 not yet assessed — every PubMed paper on record, linked below.

• From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late life ↗

  Genome Medicine · 2026 · PMID 40585142
  not yet assessed
• DNA methylation signature of cognitive reserve moderates CSF tau pathology in prodromal Alzheimer’s disease ↗

  Research Square · 2026 · PMID 41542061
  not yet assessed
• Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder ↗

  Frontiers in Immunology · 2026 · PMID 41601671
  not yet assessed
• FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis ↗

  Molecular Cancer · 2026 · PMID 41691251
  not yet assessed
• Efficient adsorptive–photocatalytic removal of organic dyes by MnO ₂ –Fe ₂ O ₃ composite prepared from pyrolusite through alkali–acid etching ↗

  Chemical Engineering Communications · 2026
  not yet assessed
• Blood DNA methylation signature of cognitive reserve moderates the association between CSF tau pathology and memory in prodromal Alzheimer's disease ↗

  Alzheimer s & Dementia Translational Research & Clinical Interventions · 2026 · PMID 42079999
  not yet assessed
• Longitudinal Blood DNA Methylation Changes During Weight-Loss Intervention and Dementia Progression Risk ↗

  Research Square · 2026 · PMID 42370254
  not yet assessed
• Multivariate Random Forests for Cross-Modal Multi-Omics Integration ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2026 · PMID 42395483
  not yet assessed
• Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma ↗

  Gastroenterology · 2026 · PMID 41770176
  not yet assessed
• Abstract 1952: Novel mouse models enabling locus-specific manipulation of DNA methylation. ↗

  Cancer Research · 2026
  not yet assessed
• Abstract 1964: Age-related <i>p16</i> epimutation is a targetable driver of <i>Kras</i> -mutant lung cancer. ↗

  Cancer Research · 2026
  not yet assessed
• Abstract 3075: FGFR2b is a highly prevalent and actionable cell surface target in intrahepatic cholangiocarcinoma ↗

  Cancer Research · 2026
  not yet assessed
• Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition ↗

  Redox Biology · 2026 · PMID 42287904
  not yet assessed
• Exploring the impact of AI-driven emotional resilience on academic persistence, motivation, cognitive flexibility, and autonomy in self-regulated learning: A self-determination theory perspective ↗

  Learning and Motivation · 2025
  not yet assessed
• First-principles investigations of electronic property modulation in the FeCl ₃ /MoSi ₂ N ₄ heterojunction by strain, interlayer distance and vertical electric field variation ↗

  RSC Advances · 2025 · PMID 40556707
  not yet assessed
• Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts ↗

  Alzheimer s & Dementia · 2025 · PMID 40133250
  not yet assessed
• DNA methylation signature of a lifestyle-based resilience index for cognitive health ↗

  Alzheimer s Research & Therapy · 2025 · PMID 40264239
  not yet assessed
• Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection

  Translational Oncology · 2025 · PMID 39754813
  L1 78/100
• Author response for "First-principles investigations of electronic property modulation in the FeCl&lt;sub&gt;3&lt;/sub&gt;/MoSi&lt;sub&gt;2&lt;/sub&gt;N&lt;sub&gt;4&lt;/sub&gt; heterojunction by strain, interlayer distance and vertical electric field variation" ↗

  2025
  not yet assessed
• DNA methylation signatures of Life’s Essential 8 and their implications for dementia ↗

  Alzheimer s Research & Therapy · 2025 · PMID 41462362
  not yet assessed
• From aging to Alzheimer's disease: concordant brain DNA methylation changes in late life ↗

  Alzheimer s & Dementia · 2025
  not yet assessed
• DNA Methylation Signature of a Lifestyle‐based Resilience Index for Cognitive Health ↗

  Alzheimer s & Dementia · 2025
  not yet assessed
• Immunotherapy in breast cancer: current landscape and emerging trends ↗

  Experimental Hematology and Oncology · 2025 · PMID 40405250
  not yet assessed
• A dual-polysaccharide (carboxylated chitosan-carboxymethyl cellulose sodium) gastrointestinal dynamic response in situ hydrogel for optimized oral targeted inflammatory bowel disease therapy ↗

  Carbohydrate Polymers · 2025 · PMID 40441821
  not yet assessed
• The diagnostic value of urinary exosomes in prostate cancer: a prospective multicenter study ↗

  BMC Urology · 2025 · PMID 41034937
  not yet assessed
• Decoding m6A readers: roles of YTHDF proteins in leukemogenesis and cancer immunity ↗

  Frontiers in Immunology · 2025 · PMID 41403953
  not yet assessed
• Advanced molecular system for accurate identification of chicken genetic resources ↗

  Computers and Electronics in Agriculture · 2025
  not yet assessed
• Exploration and validation of the prognostic value of mitophagy and mitochondrial dynamics-related genes in cervical cancer ↗

  Scientific Reports · 2025 · PMID 40640353
  not yet assessed
• Case Report: The first account of primary myeloid sarcoma of the testis combined with ipsilateral epididymal epithelioid hemangioendothelioma ↗

  Frontiers in Medicine · 2025 · PMID 40978723
  not yet assessed
• An integrative multiomics random forest framework for robust biomarker discovery ↗

  GigaScience · 2025 · PMID 41363728
  not yet assessed
• Data from Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer ↗

  2025
  not yet assessed
• Supplementary Figures from Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer ↗

  2025
  not yet assessed
• Abstract A012: Development of a translational tumoroid-organoid platform revealing tumor-specific radiosensitization in rectal cancer using matched patient-derived models ↗

  Clinical Cancer Research · 2025
  not yet assessed
• A Dual-Polysaccharide (Carboxylated Chitosan-Carboxymethyl Cellulose Sodium) Gastrointestinal Dynamic Response in Situ Hydrogel for Optimized Oral Targeted Ibd Therapy ↗

  SSRN Electronic Journal · 2025
  not yet assessed
• Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer ↗

  medRxiv · 2025 · PMID 40093220
  not yet assessed
• Abstract 739: Patient-derived xenografts allow deconvolution and prediction of chemotherapy responses ↗

  Cancer Research · 2025
  not yet assessed
• Abstract 5026: Discovery of oncogenic mediator genes in rectal cancer chemotherapy response using gene expression data from matched tumor and patient-derived organoids ↗

  Cancer Research · 2025
  not yet assessed
• Exploration and validation of the prognostic value of mitophagy and mitochondrial dynamics-related genes in cervical cancer ↗

  Research Square · 2025
  not yet assessed
• Design, Synthesis Optimization and Anticancer Activity of Small Molecule Kinase Inhibitors ↗

  International Journal of Pharmacology · 2025
  not yet assessed
• Abstract PS4-02: Patient-derived Xenografts (PDX) Allow Deconvolution of Combination Chemotherapy Response ↗

  Clinical Cancer Research · 2025
  not yet assessed
• Abstract P5-06-19: Single-cell transcriptional features of human breast tumors and model systems ↗

  Clinical Cancer Research · 2025
  not yet assessed
• Technical Mechanism and Clinical Prospects of Antigen Protein Chip in Early Detection of Cancer ↗

  International Journal of Public Health and Medical Research · 2025
  not yet assessed
• Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia ↗

  Frontiers in Oncology · 2025 · PMID 41234729
  not yet assessed
• MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment ↗

  World Journal of Oncology · 2025 · PMID 41208846
  not yet assessed
• Oncogenic role of PLOD3 mediated by SOX9 through IL-6/JAK/STAT3 pathway in cervical cancer ↗

  Cellular Signalling · 2025 · PMID 41242365
  not yet assessed
• Novel oat β-glucan nanoparticles for diabetes-associated colitis therapy ↗

  Materials Today Bio · 2025 · PMID 41492651
  not yet assessed
• Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models ↗

  Journal of Clinical Investigation · 2024 · PMID 38885332
  not yet assessed
• Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays ↗

  Epigenetics · 2024 · PMID 38564759
  not yet assessed
• Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer ↗

  Cell · 2024 · PMID 38364782
  not yet assessed
• Ensemble methods of rank-based trees for single sample classification with gene expression profiles ↗

  Journal of Translational Medicine · 2024 · PMID 38321494
  not yet assessed
• MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease ↗

  Database · 2024 · PMID 39028752
  not yet assessed
• MIAMI‐AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease ↗

  Alzheimer s & Dementia · 2024 · PMID 39750859
  not yet assessed
• High-throughput single-cell sequencing of activated sludge microbiome ↗

  Environmental Science and Ecotechnology · 2024 · PMID 39430728
  not yet assessed
• Single‐cell transcriptional atlas of human breast cancers and model systems ↗

  Clinical and Translational Medicine · 2024 · PMID 39417215
  not yet assessed
• Discovery and validation of a 10-gene predictive signature for response to adjuvant chemotherapy in stage II and III colon cancer ↗

  Cell Reports Medicine · 2024 · PMID 39059386
  not yet assessed
• Comparative evaluation of double- and single-armed two-suture longitudinal intussusception techniques in microsurgical vasoepididymostomy: An updated systematic review and meta-analysis ↗

  PLoS ONE · 2024 · PMID 38315686
  not yet assessed
• Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer ↗

  Cancer Research · 2024 · PMID 39388307
  not yet assessed
• Method evaluation for viruses in activated sludge: Concentration, sequencing, and identification ↗

  The Science of The Total Environment · 2024 · PMID 39419205
  not yet assessed
• Factors affecting patency time and semen quality in a single-armed microsurgical vasoepididymostomy ↗

  Asian Journal of Andrology · 2024 · PMID 39187925
  not yet assessed
• Unlocking the Tea Genome: Advances in High-Quality Sequencing and Annotation ↗

  Journal of Tea Science Research · 2024
  not yet assessed
• Evolution and prognostic significance of HER-2 conversion from primary to residual disease in HER-2 negative patients with breast cancer after neoadjuvant chemotherapy ↗

  American Journal of Cancer Research · 2024 · PMID 39267660
  not yet assessed
• Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39713418
  not yet assessed
• Enhancing Chemotherapy Response Prediction via Matched Colorectal Tumor-Organoid Gene Expression Analysis and Network-Based Biomarker Selection ↗

  medRxiv · 2024 · PMID 38343861
  not yet assessed
• Discovery of Oncogenic Mediator Genes in Rectal Cancer Chemotherapy Response using Gene Expression Data from Matched Tumor and Patient-Derived Organoid ↗

  medRxiv · 2024 · PMID 38352407
  not yet assessed
• Blood DNA Methylation Signature for Incident Dementia: Evidence from Longitudinal Cohorts ↗

  medRxiv · 2024 · PMID 39649611
  not yet assessed
• Photoactivatable Nanobody Conjugate Dimerizer Temporally Resolves Tiam1‐Rac1 Signaling Axis (Adv. Sci. 11/2024) ↗

  Advanced Science · 2024
  not yet assessed
• Abstract 638: FGFR4 mediates nuclear accumulation of NRF2 by binding to P62 in gastric cancer ↗

  Cancer Research · 2024
  not yet assessed
• Comparison of clinical characteristics and surgical outcomes in non‐vasectomized epididymal obstructive azoospermia patients with or without concurrent vas‐deferens obstruction ↗

  Andrology · 2024 · PMID 39132921
  not yet assessed
• Characterization of Chloroplast Genome Structure in Eucommia ulmoides ↗

  Genomics and Applied Biology · 2024
  not yet assessed
• A Novel Gastrointestinal Dynamic Response in Situ Hydrogel for Enhanced Oral Targeted Delivery in Inflammatory Bowel Disease ↗

  SSRN Electronic Journal · 2024
  not yet assessed
• Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer ↗

  Cell · 2023 · PMID 37541199
  not yet assessed
• Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects ↗

  Alzheimer s Research & Therapy · 2023 · PMID 37038196
  not yet assessed
• Transcriptome Meta-Analysis of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy ↗

  Cancers · 2023 · PMID 37190123
  not yet assessed
• MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease ↗

  medRxiv · 2023 · PMID 38105943
  not yet assessed
• Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects ↗

  Research Square · 2023 · PMID 36865230
  not yet assessed
• Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC BeadChip microarrays ↗

  Research Square · 2023
  not yet assessed
• Author response for "Epigenome‐wide &lt;scp&gt;DNA&lt;/scp&gt; methylation analysis of myasthenia gravis" ↗

  2023
  not yet assessed
• Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC BeadChip microarrays for dementia research ↗

  Research Square · 2023 · PMID 37461726
  not yet assessed
• Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis ↗

  Redox Biology · 2023 · PMID 38154380
  not yet assessed
• A workflow to study mechanistic indicators for driver gene prediction with Moonlight ↗

  Briefings in Bioinformatics · 2023 · PMID 37551622
  not yet assessed
• Systemically Identifying Triple-Negative Breast Cancer Subtype-Specific Prognosis Signatures, Based on Single-Cell RNA-Seq Data ↗

  Cells · 2023 · PMID 36766710
  not yet assessed
• Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease ↗

  Nature Communications · 2022 · PMID 35982059
  not yet assessed
• Distinct sex-specific DNA methylation differences in Alzheimer’s disease ↗

  Alzheimer s Research & Therapy · 2022 · PMID 36109771
  not yet assessed
• MethReg: estimating the regulatory potential of DNA methylation in gene transcription ↗

  Nucleic Acids Research · 2022 · PMID 35100398
  not yet assessed
• Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling ↗

  Nature Immunology · 2022 · PMID 35449416
  not yet assessed
• Cross-tissue meta-analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease ↗

  medRxiv · 2022
  not yet assessed
• Additional file 2 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease ↗

  Figshare · 2022
  not yet assessed
• Decision letter: Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs ↗

  2022
  not yet assessed
• An Automatized Workflow to Study Mechanistic Indicators for Driver Gene Prediction with Moonlight ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2022
  not yet assessed
• Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes ↗

  Nature Communications · 2021 · PMID 34725325
  not yet assessed
• A <scp>SMAD4</scp> ‐modulated gene profile predicts disease‐free survival in stage <scp>II</scp> and <scp>III</scp> colorectal cancer ↗

  Cancer Reports · 2021 · PMID 34114372
  not yet assessed
• PathwayMultiomics: An R Package for Efficient Integrative Analysis of Multi-Omics Datasets With Matched or Un-matched Samples ↗

  Frontiers in Genetics · 2021 · PMID 35003218
  not yet assessed
• LR Hunting: A Random Forest Based Cell–Cell Interaction Discovery Method for Single-Cell Gene Expression Data ↗

  Frontiers in Genetics · 2021 · PMID 34497635
  not yet assessed
• A Claudin-Based Molecular Signature Identifies High-Risk, Chemoresistant Colorectal Cancer Patients ↗

  Cells · 2021 · PMID 34571860
  not yet assessed
• Additional file 10 of CRISPR/Cas9 mediated T7 RNA polymerase gene knock-in in E. coli BW25113 makes T7 expression system work efficiently ↗

  Open MIND · 2021
  not yet assessed
• Additional file 7 of CRISPR/Cas9 mediated T7 RNA polymerase gene knock-in in E. coli BW25113 makes T7 expression system work efficiently ↗

  Figshare · 2021
  not yet assessed
• Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy ↗

  Cell · 2020 · PMID 33212010
  not yet assessed
• Proteogenomic Characterization of Endometrial Carcinoma ↗

  Cell · 2020 · PMID 32059776
  not yet assessed
• Interpreting pathways to discover cancer driver genes with Moonlight ↗

  Nature Communications · 2020 · PMID 31900418
  not yet assessed
• Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma ↗

  Cell · 2020
  not yet assessed
• Mutant IDH1 Depletion Downregulates Integrins and Impairs Chondrosarcoma Growth ↗

  Cancers · 2020 · PMID 31935911
  not yet assessed
• Interpreting pathways to discover cancer driver genes with Moonlight ↗

  F1000Research · 2020
  not yet assessed
• Author response for "Growth inhibition and suppression of the mTOR and Wnt/beta-catenin pathways in T-acute lymphoblastic leukemia by rapamycin and MYCN depletion" ↗

  2020
  not yet assessed
• Abstract 5118: Proteogenomics characterization of HPV-negative head and neck squamous cell carcinomas ↗

  Cancer Research · 2020
  not yet assessed
• Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma ↗

  Cell · 2019 · PMID 31675502
  not yet assessed
• The mechanism of cancer drug addiction in ALK-positive T-Cell lymphoma ↗

  Oncogene · 2019 · PMID 31804622
  not yet assessed
• coMethDMR: Accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies ↗

  bioRxiv (Cold Spring Harbor Laboratory) · 2019
  not yet assessed
• Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation ↗

  Blood · 2018 · PMID 30573634
  not yet assessed
• Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure ↗

  Leukemia · 2018 · PMID 30275527
  not yet assessed
• Aberrant activation of Hedgehog/Gli1 pathway on angiogenesis in gliomas ↗

  Neurology India · 2012 · PMID 23287320
  not yet assessed