Kei‐ichi Ishikawa
Reproducibility track record
1
assessed papers
100/100
mean reproducibility
1
reproduced (C1–C2)
0
flagged
11
total citations
flag rate:
0%
(0/1)
The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.
Authorship role
first author: 0
last author: 0
Topics
Funders
—
Frequent co-authors
Nobutaka Hattori 1Wataru Sako 1Genko Oyama 1Tatou Iseki 1Tetsushi Kataura 1Taku Hatano 1Yukiko Sasazawa 1Ayami Suzuki 1Kenta Shiina 1Shinji Saiki 1
Institutions
Juntendo University 1University of Tsukuba 1RIKEN Center for Brain Science 1
Geography (author institutions)
JP 1
Co-author network
Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.
How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.
Assessed papers (1)
Complete publication record (133)
Request a reproduction →1 assessed by us (1 reproduced) · 132 not yet assessed — every PubMed paper on record, linked below.
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Adaptation-dependent modulation of coordinated muscle activities in human gait adaptation as revealed by tensor decomposition ↗iScience · 2026 · PMID 41890974not yet assessed
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Suppression of ATM kinase signaling accelerates cellular senescence ↗Stem Cell Reports · 2026 · PMID 42276063not yet assessed
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A <scp>PARK9 iPSC</scp> ‐Derived Dopaminergic Neuron Model Enables Drug Screening Targeting Autophagy‐Lysosome Pathway Dysfunction in Parkinson's Disease ↗Journal of Neurochemistry · 2026 · PMID 42400323not yet assessed
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The UFSP2-ODR4 complex spatially confines and dynamically controls UFM1 deconjugation to safeguard neuronal proteostasis ↗Molecular Cell · 2026 · PMID 42425078not yet assessed
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Generation of hiPSCs (JUCGRMi008-A) from a β-propeller protein-associated neurodegeneration patient with WDR45 mutation ↗Stem Cell Research · 2026 · PMID 42119323not yet assessed
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Alpha-Synuclein Inhibits the Secretion of Extracellular Vesicles through Disruptions in YKT6 Lipidation ↗Journal of Neuroscience · 2025 · PMID 39794126not yet assessed
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Randomised, double-blind, placebo-controlled, parallel-group study to assess the efficacy and safety of antibiotic faecal microbiota transplantation in patients with Parkinson’s disease (FLORA-PD): a study protocol ↗BMJ Open · 2025 · PMID 41120147not yet assessed
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Establishment of an In Vitro Disease Model of Charcot-Marie-Tooth Disease using Human Induced Pluripotent Stem Cells ↗Juntendō Igaku/Juntendo igaku · 2025 · PMID 40666492not yet assessed
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not yet assessed
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Fully automated segmentation of substantia nigra toward longitudinal analysis of Parkinson’s disease ↗International Journal of Computer Assisted Radiology and Surgery · 2025 · PMID 41051626not yet assessed
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Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation ↗The EMBO Journal · 2025 · PMID 41087580not yet assessed
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Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025not yet assessed
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Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication ↗Stem Cell Research · 2024 · PMID 38537501not yet assessed
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Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation ↗Stem Cell Research · 2024 · PMID 38309147not yet assessed
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Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity ↗Neuroscience Research · 2024 · PMID 39617169not yet assessed
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Comprehensive Gene Expression Analysis Using Human Induced Pluripotent Stem Cells Derived from Patients with Sleep Bruxism: A Preliminary In Vitro Study ↗International Journal of Molecular Sciences · 2024 · PMID 39684851not yet assessed
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Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson’s disease patientsScientific Data · 2024 · PMID 39406833L1 100/100
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not yet assessed
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Generation of an induced pluripotent stem cell line from a late-onset, progressive high frequency hearing loss patient due to mutation in CDH23 ↗Stem Cell Research · 2024 · PMID 38878669not yet assessed
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Preliminary study of substantia nigra analysis by tensorial feature extraction ↗International Journal of Computer Assisted Radiology and Surgery · 2024 · PMID 38935246not yet assessed
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A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease ↗Frontiers in Neuroscience · 2023 · PMID 37502682not yet assessed
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Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines ↗Frontiers in Cell and Developmental Biology · 2023 · PMID 37745304not yet assessed
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Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2 ↗EMBO Molecular Medicine · 2023 · PMID 37578019not yet assessed
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Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes ↗Stem Cell Research · 2023 · PMID 38100911not yet assessed
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Generation of three clones (JUCGRMi002-A, B, C) of induced pluripotent stem cells from a Parkinson’s disease patient with SNCA duplication ↗Stem Cell Research · 2023 · PMID 38154385not yet assessed
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Assessment of iPS Cell-derived Dopaminergic Progenitor Cells Properties with Long-term Passaging and Amplification ↗Juntendō Igaku/Juntendo igaku · 2023 · PMID 38855954not yet assessed
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Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes ↗Stem Cell Research · 2023 · PMID 38100917not yet assessed
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Autophagy promotes cell survival by maintaining NAD levels ↗Developmental Cell · 2022 · PMID 36413951not yet assessed
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Generation of three hiPSC clones from a Parkinson’s disease patient with a heterozygous variant of VPS35 p.D620N ↗Stem Cell Research · 2022 · PMID 35247840not yet assessed
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Gastric volvulus with esophageal hiatal hernia treated by percutaneous endoscopic gastrostomy ↗Progress of Digestive Endoscopy · 2022not yet assessed
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Autophagy is Required for the Maintenance of NAD ↗SSRN Electronic Journal · 2022not yet assessed
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Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons ↗Molecular Brain · 2021 · PMID 33757554not yet assessed
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Uniaxially fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis ↗Scientific Reports · 2021 · PMID 33907271not yet assessed
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Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells ↗Methods in molecular biology · 2021 · PMID 34043194not yet assessed
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Methods to Induce Small-Scale Differentiation of iPS Cells into Dopaminergic Neurons and to Detect Disease Phenotypes ↗Methods in molecular biology · 2021 · PMID 33755905not yet assessed
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Causal Connection Between Serum Levodopa Metabolic Profile and Medication in Parkinson’s Disease ↗Research Square · 2021not yet assessed
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Publisher Correction: Uniaxially fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis ↗Scientific Reports · 2021 · PMID 34183704not yet assessed
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Autophagy promotes cell survival by maintaining NAD(H) levels ↗Research Square · 2021not yet assessed
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iPSC-based Drug Screening for PARK9, a Familial Parkinson’s Disease with Impaired Autophagy ↗Juntendō Igaku/Juntendo igaku · 2021not yet assessed
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not yet assessed
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Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease ↗Brain · 2020 · PMID 32201884not yet assessed
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Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation ↗Journal of Neuroscience · 2020 · PMID 33046546not yet assessed
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Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease ↗Stem Cell Reports · 2020 · PMID 32470327not yet assessed
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Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations ↗npj Parkinson s Disease · 2020 · PMID 33298969not yet assessed
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A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling ↗iScience · 2020 · PMID 32335362not yet assessed
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Shared Metabolic Profile of Caffeine in Parkinsonian Disorders ↗Movement Disorders · 2020 · PMID 32357260not yet assessed
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BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model ↗Journal of Neurochemistry · 2020 · PMID 32128811not yet assessed
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Perforated duodenal diverticulum successfully treated with a combination of surgical drainage and endoscopic nasobiliary and nasopancreatic drainage: a case report ↗Surgical Case Reports · 2020 · PMID 32514821not yet assessed
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IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
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Intracellular Tension of Osteoblasts in Collagen Matrix Under Uniaxially-Fixed Boundary Condition Elicits Osteocyte Alignment with Induction of Osteogenesis ↗SSRN Electronic Journal · 2020not yet assessed
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Mutations in CHCHD2 cause α-synuclein aggregation ↗Human Molecular Genetics · 2019 · PMID 31600778not yet assessed
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Metabolomics‐based identification of metabolic alterations in PARK2 ↗Annals of Clinical and Translational Neurology · 2019 · PMID 30911576not yet assessed
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Neuroprotective effects of memantine via enhancement of autophagy ↗Biochemical and Biophysical Research Communications · 2019 · PMID 31431260not yet assessed
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Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy ↗PLoS ONE · 2019 · PMID 31560709not yet assessed
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Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson’s Disease ↗Scientific Data · 2019 · PMID 30952910not yet assessed
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A High-Throughput Disease-Specific Phenotype Detection System of Parkinson’s Disease ↗Juntendō Igaku/Juntendo igaku · 2019not yet assessed
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Cellular alignment of differentiated osteocytes on collagen gels and three-dimensional cell migration into gels. ↗Baioenjiniaringu Koenkai koen ronbunshu/Baioenjiniaringu Kouenkai kouen rombunshuu/Ippan Shadan Hojin Nihon Kikai Gakkai Baioenjiniaringu Koenkai · 2019not yet assessed
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Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease ↗Proceedings of the National Academy of Sciences · 2018 · PMID 29735655not yet assessed
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Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease ↗Neurology · 2018 · PMID 29298852not yet assessed
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p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery ↗Neuroscience Letters · 2018 · PMID 30366015not yet assessed
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Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease ↗Cells · 2018 · PMID 30597973not yet assessed
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A Key Role of Soluble Epoxide Hydrolase in the Pathogenesis of Parkinson's Disease ↗The FASEB Journal · 2018not yet assessed
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The effect of intracellular tension on self-alignment of osteoblast-like cells on gels ↗Baioenjiniaringu Koenkai koen ronbunshu/Baioenjiniaringu Kouenkai kouen rombunshuu/Ippan Shadan Hojin Nihon Kikai Gakkai Baioenjiniaringu Koenkai · 2018not yet assessed
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Mechanism for Cellular Alignment of Differentiated Osteocytes in 3D Cell Culture Systems ↗The Proceedings of Mechanical Engineering Congress Japan · 2018not yet assessed
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High throughput assays to detect disease-specific abnormalities in familial PD-iPSC derived neuronsJapanese Society of Neurology · 2018not yet assessed
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Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease ↗Scientific Reports · 2017 · PMID 28779141not yet assessed
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Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons ↗Biochemical and Biophysical Research Communications · 2017 · PMID 28057485not yet assessed
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Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease ↗Human Molecular Genetics · 2017 · PMID 28541509not yet assessed
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Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells ↗Methods in molecular biology · 2017 · PMID 28361483not yet assessed
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Assessment of Mitophagy in iPS Cell-Derived Neurons ↗Methods in molecular biology · 2017 · PMID 28324490not yet assessed
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Plasma metabolomics reveals low levels of antioxidants in PSP ↗Journal of the Neurological Sciences · 2017not yet assessed
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Electronystagmographical studies of a patient with spinocerebellar ataxia type 6 (SCA 6) mainly complaining of the positional vertigo ↗Equilibrium Research · 2017not yet assessed
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Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models ↗Journal of the Neurological Sciences · 2017not yet assessed
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Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation ↗Biochemical and Biophysical Research Communications · 2016 · PMID 26851368not yet assessed
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Improving the Quality of Postgraduate Education in Traditional Japanese Kampo Medicine for Junior Residents: An Exploratory Survey Conducted in Five Institutions in the Tohoku Area ↗The Tohoku Journal of Experimental Medicine · 2016 · PMID 27890870not yet assessed
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Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's diseaseThe Molecular Biology Society of Japan · 2016not yet assessed
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Endoscopic biliary drainage as a bridging procedure to single-stage surgery for perforated choledochal cyst: a case report and review of the literature ↗Surgical Case Reports · 2015 · PMID 26943441not yet assessed
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Pathophysiological analysis of Parkinson's disease using iPS cells. ↗PubMed · 2015 · PMID 30458085not yet assessed
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p150glued-Associated Disorders Are Caused by Activation of Intrinsic Apoptotic Pathway ↗PLoS ONE · 2014 · PMID 24722468not yet assessed
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Serum Uric Acid Concentration is Linked to Wearing-off Fluctuation in Japanese Parkinson's Disease Patients ↗Journal of Parkinson s Disease · 2014 · PMID 24784037not yet assessed
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Effects of donepezil dose escalation in <scp>P</scp>arkinson's patients with dementia receiving long‐term donepezil treatment: an exploratory study ↗Psychogeriatrics · 2014 · PMID 24661498not yet assessed
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A case of rectal bleeding successfully treated by endoscopic band ligation ↗Progress of Digestive Endoscopy · 2014not yet assessed
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A case of enterocutaneous fistula diagnosed by colonoscopy ↗Progress of Digestive Endoscopy · 2014not yet assessed
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A case of appendiceal bleeding with hemostasis successfully performed by endoscopic-clipping ↗Progress of Digestive Endoscopy · 2013not yet assessed
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A case of cholecystocolonic fistula successfully diagnosed by colonoscopy ↗Progress of Digestive Endoscopy · 2013not yet assessed
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A case of carcinoma of the esophagus with mixed basaloid squamous and glandular differentiation ↗Progress of Digestive Endoscopy · 2013not yet assessed
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Insertion of a duodenal stent using the ‘stent-in-stent’ method providing useful treatment for duodenal stenosis caused by progression of gastric cancer ↗Progress of Digestive Endoscopy · 2013not yet assessed
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Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS ↗Parkinsonism & Related Disorders · 2012 · PMID 22818528not yet assessed
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A case of gastric cancer evaluated by combination of using endoscopy and CT gastrography ↗Progress of Digestive Endoscopy · 2012not yet assessed
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Clinico-histopathological analysis of hepatocellular carcinoma invading the biliary tract ↗Kanzo · 2011not yet assessed
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Crowned Dens Syndrome Mimicking Meningitis ↗Internal Medicine · 2010 · PMID 20847512not yet assessed
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Fading Out Dip-and-Plateau Pattern of Right Ventricular Pressure in Constrictive Pericarditis ↗Circulation · 2010 · PMID 20660816not yet assessed
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A case of malignant melanoma with metastases to the stomach ↗Progress of Digestive Endoscopy · 2010not yet assessed
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Effective control of catatonia in Parkinson’s disease by electroconvulsive therapy: a case report ↗European Journal of Neurology · 2008 · PMID 19146631not yet assessed
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New Classification of Anal Fistula: Clarifying Low Intersphincteric Fistula and Posterior Complex Fistula ↗Nihon Daicho Komonbyo Gakkai Zasshi · 2008not yet assessed
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Extranodal metastasis is an indicator of poor prognosis in patients with gastric carcinoma ↗British journal of surgery · 2006 · PMID 16392106not yet assessed
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Soil animals from 88 temples in Shikoku Island [Japan], 4: Morphological variation in the nineteen known species of oribatid mites2006not yet assessed
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Preoperative Parameters Expanding the Indication of Sphincter Preserving Surgery in Patients With Advanced Low Rectal Cancer ↗Annals of Surgery · 2003 · PMID 14685098not yet assessed
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Extranodal Cancer Deposit at the Primary Tumor Site and the Number of Pulmonary Lesions Are Useful Prognostic Factors After Surgery for Colorectal Lung Metastases ↗Diseases of the Colon & Rectum · 2003 · PMID 12792439not yet assessed
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T-Tube Management of a Major Leakage of the Cervical Esophagogastrostomy After Subtotal Esophagectomy: Report of Three Cases ↗Surgery Today · 2003 · PMID 14669086not yet assessed
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A CASE OF MALT LYMPHOMA OF THE RECTUM WITH SYNCHRONOUS RECTAL CANCER AND SYSTEMIC SPREAD OF RECURRENT BILATERAL BREAST CANCER ↗Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · 2003not yet assessed
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Periodate-treated, non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) affects angiogenesis and inhibits subcutaneous induced tumour growth and metastasis to the lung ↗British Journal of Cancer · 2002 · PMID 12087470not yet assessed
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The Accuracy and Clinical Significance of Histopathological Findings in the Submucosal Invasive front of Rectal Carcinoma, Obtained by Preoperative Transanal Punch biopsy. ↗Nihon Daicho Komonbyo Gakkai Zasshi · 2002not yet assessed
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Postoperative Prognostic Factors in Lung Metastasis from Colorectal Cancer with Special Reference to Primary Lesion Features. ↗Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · 2002not yet assessed
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A linkage disequilibrium at the candidate gene locus for 16q-linked autosomal dominant cerebellar ataxia type III in Japan ↗Journal of Human Genetics · 2001 · PMID 11322654not yet assessed
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Classification of left colonic transit patterns after low anterior resection and it's relation to defecatory symptoms. ↗Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · 2001not yet assessed
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Treatment Strategies for Colorectal Liver Metastases Based on Analysis of Prognostic Factors. ↗日本消化器外科学会雑誌 · 2001not yet assessed
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Study on the understanding of the patients for their oral care during the periodontal treatment in 1995 and 2000Medical Entomology and Zoology · 2001not yet assessed
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Photocrosslinkable chitosan as a biological adhesive ↗Journal of Biomedical Materials Research · 2000 · PMID 10571917not yet assessed
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Photocrosslinkable chitosan as a biological adhesive ↗Journal of Biomedical Materials Research · 2000not yet assessed
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Heparin-carrying polystyrene to mediate cellular attachment and growth via interaction with growth factors ↗Journal of Biomedical Materials Research · 2000 · PMID 10679678not yet assessed
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Enhanced Ability of Heparin-Carrying Polystyrene (HCPS) to Bind to Heparin-Binding Growth Factors and to Inhibit Growth Factor-Induced Endothelial Cell Growth ↗The Journal of Biochemistry · 2000 · PMID 10788788not yet assessed
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Heparin-carrying polystyrene to mediate cellular attachment and growth via interaction with growth factors ↗Journal of Biomedical Materials Research · 2000not yet assessed
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A CASE OF PERINEAL PAGET'S DISEASE TREATED BY WIDE EXCISION AND SKIN GRAFTING ↗Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · 2000not yet assessed
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Preparation of heparin-carrying polystyrene(HCPS)and control of various cell growthes.Connective tissue · 2000not yet assessed
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Effects of terrestrial weathering on the matrix mineralogy of Colony CO3 chondrite ↗Institutional Repositories DataBase (IRDB) · 1999not yet assessed
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38 Cases of Atraumatic Colorectal Perforation : Clinical Significance of Free Air and Abdominal SignsMedical Entomology and Zoology · 1999not yet assessed
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Preparation of Large Ice Crystals by Controlling the Difference between Solution and Coolant Temperatures and Its Application to Freeze Concentration. ↗NIPPON SHOKUHIN KOGYO GAKKAISHI · 1997not yet assessed
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Combination therapy with cisplatin, 5'-deoxy-5-fluorouridine (5'-DFUR) and mitomycin (MMC) in patients with inoperable, advanced gastric cancer ↗Oncology Reports · 1996 · PMID 21594354not yet assessed
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Matrix of Colony (CO3) chondrite.1995not yet assessed
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Freezing and Eutectic Points of an Aqueous Amino Acid Solution Containing Ethanol, and the Effect of Ethanol Addition on the Freeze Concentration Process ↗Bioscience Biotechnology and Biochemistry · 1994not yet assessed
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not yet assessed
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TWO CASES OF JEJUNAL INTUSSUSCEPTION AFTER GASTRECTOMY DIAGNOSED BY CT SCAN ↗The journal of the Japanese Practical Surgeon Society · 1993not yet assessed
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Studies on the development of tea [Camellia sinensis]-plucking machine, 2: Development of tea-plucking system1993not yet assessed
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Rb-Sr isotopic study of Yamato-794046 and its inclusion.1993not yet assessed
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[A case of occupational grape pollinosis]. ↗PubMed · 1984 · PMID 6477137not yet assessed
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[Neurinoma in the region of the pancreatic head--a case report with angiographic consideration (author's transl)]. ↗PubMed · 1980 · PMID 7441898not yet assessed
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The Reactions of 2-Arylacetylene-1-sulfonamides with Heterocumulenes ↗Bulletin of the Chemical Society of Japan · 1978not yet assessed
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[Debates on brain biopsy and psychosurgery: concerning the "Miyakawa Article" (author's transl)]. ↗PubMed · 1976 · PMID 989912not yet assessed
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[The clinical significance of the width of the avascular area in the retinopathy of prematurity (author's transl)]. ↗PubMed · 1976 · PMID 1034420not yet assessed
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[Case of empty sella syndrome in an obese woman]. ↗PubMed · 1974 · PMID 4472668not yet assessed
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[Historical ground for drug therapy in neuropsychology]. ↗PubMed · 1974 · PMID 4619476not yet assessed
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Physiological and Ecological Features of Citrus Root-Stocks, Part I : "On the resistance to submersion, drought and shade"Medical Entomology and Zoology · 1959not yet assessed
Full bibliography from OpenAlex; reproducibility verdicts matched by PMID.
Author attribution follows OpenAlex disambiguation, which is imperfect — a researcher's papers can be split across profiles or mixed with a namesake.
Merged across profiles sharing this ORCID where present. See every “Ishikawa K” paper on PubMed ↗