Grant A. Challen
Reproducibility track record
1
assessed papers
73/100
mean reproducibility
0
reproduced (C1–C2)
0
flagged
0
total citations
flag rate:
0%
(0/1)
The share of this author’s assessed papers carrying a ⚑ flag. A concentration is a prompt for expert review — never, on its own, a determination about the person.
Authorship role
first author: 0
last author: 0
Topics
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Funders
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Frequent co-authors
Alexander B. Kim 1Stacey Rentschler 1Mary C. Fulbright 1Kailen Mark 1Sandra E. Dunn 1Fan He 1Li Ding 1Daniel A.C. Fisher 1Jingxian Liu 1LaYow Yu 1
Institutions
Washington University in St. Louis 1Stanford University 1James S. McDonnell Foundation 1Quantum Design (United States) 1
Geography (author institutions)
US 1
Co-author network
Collaborators, sized by shared output and coloured by their own reproducibility (green = high, red = low). Click a node to open their card. A pattern is a prompt for review, never a determination.
How this author’s assessed papers reproduced — the outcome of reproduction attempts, not a judgement of the person. Coverage is partial and grows over time.
Assessed papers (1)
Complete publication record (228)
Request a reproduction →1 assessed by us (0 reproduced) · 227 not yet assessed — every PubMed paper on record, linked below.
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JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation ↗Blood Advances · 2026 · PMID 40950155not yet assessed
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Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment ↗Stem Cell Reports · 2026 · PMID 41650958not yet assessed
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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia ↗Cell Reports Medicine · 2026 · PMID 41850232not yet assessed
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Abstract 5241: Personalized fusion measurable residual disease detection in acute myeloid leukemia using droplet digital PCR ↗Cancer Research · 2026not yet assessed
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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia ↗Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2026not yet assessed
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TET2 loss triggers ssDNA gap accumulation and heightened PARP inhibitor sensitivity ↗Nature Communications · 2026not yet assessed
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Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis ↗Nature Communications · 2025 · PMID 40240771not yet assessed
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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemiaNature Communications · 2025 · PMID 39820365L1 73/100
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Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity ↗Cell stem cell · 2025 · PMID 40680747not yet assessed
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Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis ↗Experimental Hematology · 2025 · PMID 40412746not yet assessed
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Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 40161782not yet assessed
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Parallel Evolution of Leukemic Clones in Myeloproliferative Neoplasms ↗Research Square · 2025 · PMID 41333431not yet assessed
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Abstract 1916: Oncogenic fusion detection for leukemia patients using droplet digital PCR ↗Cancer Research · 2025not yet assessed
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Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 40791535not yet assessed
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JAK2 V617F Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025 · PMID 41040409not yet assessed
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MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state ↗bioRxiv (Cold Spring Harbor Laboratory) · 2025not yet assessed
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RSK1 dependency in FLT3-ITD acute myeloid leukemia ↗Blood Cancer Journal · 2024 · PMID 39592591not yet assessed
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Spatial Mapping of Hematopoietic Clones in Human Bone Marrow ↗Blood Cancer Discovery · 2024 · PMID 38421682not yet assessed
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BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis ↗Blood Neoplasia · 2024 · PMID 40552132not yet assessed
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Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres ↗Blood · 2024not yet assessed
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Enhanced Molecular Response in Myeloproliferative Neoplasms with Complete JAK2V617F Inhibition ↗Cancer Discovery · 2024 · PMID 38690601not yet assessed
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DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells ↗bioRxiv (Cold Spring Harbor Laboratory) · 2024 · PMID 39411165not yet assessed
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In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition ↗Blood · 2024not yet assessed
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EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis ↗Blood · 2024not yet assessed
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KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress ↗Leukemia · 2023 · PMID 36797416not yet assessed
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Droplet Digital PCR for Oncogenic KMT2A Fusion Detection ↗Journal of Molecular Diagnostics · 2023 · PMID 37813299not yet assessed
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Supplementary Figure from Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21 ↗2023not yet assessed
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Data from LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms ↗2023not yet assessed
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Data from LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms ↗2023not yet assessed
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Supplementary Figure from Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21 ↗2023not yet assessed
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3077 – JARID2-MEDIATED EPIGENETIC REPROGRAMMING OF HUMAN HEMATOPOIETIC PROGENITORS FOR STEM CELL TRANSPLANTATION ↗Experimental Hematology · 2023not yet assessed
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3225 – DNA METHYLATION-INDEPENDENT FUNCTIONS OF DNMT3A REGULATE HEMATOPOIETIC STEM CELL FUNCTION ↗Experimental Hematology · 2023not yet assessed
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3056 – DNMT3A MUTATIONS UPREGULATE CELL ADHESION MOLECULES TO PROMOTE INVASIVENESS OF T-ALL CELLS ↗Experimental Hematology · 2023not yet assessed
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Engineering a humanized animal model of polycythemia vera with minimal JAK2V617F mutant allelic burden ↗Haematologica · 2023 · PMID 37767551not yet assessed
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The Tetraspanin CD53 Promotes the Clonal Advantage of Dnmt3a-Deficient Hematopoietic Stem Cells ↗Blood · 2023not yet assessed
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Leukemic Driver Clones Can Arise Independently and Outcompete MPN Cells in Post-MPN Secondary AML ↗Blood · 2023not yet assessed
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Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis ↗Cancer Discovery · 2022 · PMID 36169447not yet assessed
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DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression ↗Nature Cancer · 2022 · PMID 36581736not yet assessed
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Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 ↗Blood Cancer Discovery · 2022 · PMID 35394496not yet assessed
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Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV ↗Experimental Hematology · 2022 · PMID 35940373not yet assessed
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Dnmt3a Loss-of-Function Enhances DNA Repair in Proliferative HSCs Under Inflammatory Stress ↗Blood · 2022not yet assessed
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Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis ↗bioRxiv (Cold Spring Harbor Laboratory) · 2022not yet assessed
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Abstract LB555: Augmented Txnip-p53-p21 axis preserves Dnmt3a mutant hematopoietic stem cells during inflammatory stress ↗Cancer Research · 2022not yet assessed
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KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress ↗Research Square · 2022not yet assessed
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131. Clonal Hematopoiesis is associated with risk of Cardiovascular Disease in individuals with Human Immunodeficiency Virus ↗Cancer Genetics · 2022not yet assessed
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Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera ↗Blood · 2022not yet assessed
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Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling ↗Cell stem cell · 2021 · PMID 33743191not yet assessed
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Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification ↗Experimental Hematology · 2021 · PMID 34648848not yet assessed
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TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors ↗Cancer Research · 2021 · PMID 34215619not yet assessed
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LKB1/ STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms ↗Cancer Discovery · 2021 · PMID 33579786not yet assessed
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Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF ↗PLoS Pathogens · 2021 · PMID 34019588not yet assessed
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Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition ↗Blood Advances · 2021 · PMID 34644371not yet assessed
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3042 – TXNIP ENHANCES FITNESS OF DNMT3A-MUTANT HEMATOPOIETIC STEM CELLS VIA P21 ↗Experimental Hematology · 2021not yet assessed
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DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression ↗bioRxiv (Cold Spring Harbor Laboratory) · 2021not yet assessed
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DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression ↗Blood · 2021not yet assessed
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DNMT3A Regulates Hematopoietic Stem Cell Function Via DNA Methylation-Independent Functions ↗Blood · 2021not yet assessed
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A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms ↗Cancer Discovery · 2021 · PMID 34193440not yet assessed
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Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones ↗Blood · 2020 · PMID 32746453not yet assessed
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Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness ↗Stem Cell Reports · 2020 · PMID 32220332not yet assessed
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Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow ↗Oncotarget · 2020 · PMID 32477458not yet assessed
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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment ↗Cell Reports · 2020 · PMID 33027668not yet assessed
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Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma ↗Retrovirology · 2020 · PMID 32859220not yet assessed
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Dnmt3a is essential for hematopoietic stem cell differentiation ↗Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2020not yet assessed
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A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms ↗bioRxiv (Cold Spring Harbor Laboratory) · 2020not yet assessed
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Loss of LKB1/STK11 Facilitates Leukemic Progression of the Myeloproliferative Neoplasms ↗Blood · 2020not yet assessed
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A Novel Humanized Animal Model Reveals Clonal Architecture and Therapeutic Vulnerabilities in Myelofibrosis ↗Blood · 2020not yet assessed
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IFNg Signaling is a Driver of Dnmt3a-Mutant Clonal Hematopoiesis ↗SSRN Electronic Journal · 2020not yet assessed
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Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients ↗Experimental Hematology · 2019 · PMID 31812712not yet assessed
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Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis ↗Leukemia · 2019 · PMID 30936419not yet assessed
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IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer ↗JCI Insight · 2019 · PMID 31527315not yet assessed
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Radiation Induces Iatrogenic Immunosuppression by Indirectly Affecting Hematopoiesis in Bone Marrow ↗SSRN Electronic Journal · 2019not yet assessed
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1014 - THE PRC2 CO-FACTOR JARID2 IS A KEY REGULATOR OF NORMAL AND NEOPLASTIC HEMATOPOIESIS ↗Experimental Hematology · 2019not yet assessed
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Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo ↗Cell Reports · 2018 · PMID 29617651not yet assessed
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Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance ↗Nature Communications · 2018 · PMID 29593283not yet assessed
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A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia ↗Cancer Cell · 2018 · PMID 29316427not yet assessed
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JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells ↗Cancer Cell · 2018 · PMID 30423295not yet assessed
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An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia ↗Journal of Biological Chemistry · 2018 · PMID 29540473not yet assessed
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JARID2 Restricts Self-Renewal Capacity in Hematopoietic Progenitors and is A Myeloid Tumor Suppressor ↗Experimental Hematology · 2018not yet assessed
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Dnmt3a regulates T-cell development and suppresses T-ALL transformation ↗Leukemia · 2017 · PMID 28321121not yet assessed
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Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia ↗Clinical Cancer Research · 2017 · PMID 29127121not yet assessed
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Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis ↗Cell stem cell · 2017 · PMID 28061354not yet assessed
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The GNASR201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity ↗Experimental Hematology · 2017 · PMID 28939416not yet assessed
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Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults ↗Nature Communications · 2016 · PMID 27546487not yet assessed
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Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation ↗Biology Open · 2016 · PMID 27170255not yet assessed
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DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias ↗Cancer Cell · 2016 · PMID 27300438not yet assessed
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The epigenetic basis of hematopoietic stem cell aging ↗Seminars in Hematology · 2016 · PMID 28088983not yet assessed
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DNA methylation in normal and malignant hematopoiesis ↗International Journal of Hematology · 2016 · PMID 26943352not yet assessed
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Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? ↗Experimental Hematology · 2016 · PMID 27423816not yet assessed
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DNMT3A regulates T-cell development and suppresses T-all transformation ↗Experimental Hematology · 2016not yet assessed
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Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells ↗Experimental Hematology · 2015 · PMID 26143581not yet assessed
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Pathways for Oncogenesis in T-Cell Acute Lymphoblastic Leukemia Driven By DNA Methylation and Notch Signaling ↗Blood · 2015not yet assessed
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Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells ↗Cell stem cell · 2014 · PMID 25130491not yet assessed
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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation ↗Blood · 2014 · PMID 25416277not yet assessed
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Type II Interferon Promotes Differentiation of Myeloid-Biased Hematopoietic Stem Cells ↗Stem Cells · 2014 · PMID 25078851not yet assessed
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Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation ↗Blood · 2014 · PMID 25416276not yet assessed
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Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells ↗Experimental Hematology · 2014not yet assessed
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Role of DNA Methyltransferases and DNA Methylation in Cell Fate Decisions During Blood Cell Development and Leukemia ↗Epigenetics and human health · 2014not yet assessed
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Large conserved domains of low DNA methylation maintained by Dnmt3a ↗Nature Genetics · 2013 · PMID 24270360not yet assessed
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Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors ↗Experimental Hematology · 2013 · PMID 24373928not yet assessed
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Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a ↗Blood · 2013not yet assessed
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De novo DNA methylation is required for maintaining genomic and transcriptional integrity in hematopoietic stem cells ↗Experimental Hematology · 2013not yet assessed
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Isolation and Characterization of Mouse Side Population Cells ↗Methods in molecular biology · 2012 · PMID 23179831not yet assessed
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Dnmt3a Deletion and FLT3-ITD Cooperate in a Mouse Model of T-Lymphoblastic Leukemia (T-ALL). ↗Blood · 2012not yet assessed
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Dnmt3a is essential for hematopoietic stem cell differentiation ↗Nature Genetics · 2011 · PMID 22138693not yet assessed
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Hematopoietic Stem Cell Characterization and Isolation ↗Methods in molecular biology · 2011 · PMID 21618082not yet assessed
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Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro ↗Journal of Orthopaedic Research® · 2011 · PMID 21495066not yet assessed
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Bridge Over Troubled Stem Cells ↗Molecular Therapy · 2011 · PMID 21964307not yet assessed
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Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1 ↗Cell stem cell · 2010 · PMID 20207229not yet assessed
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Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells ↗Experimental Hematology · 2010 · PMID 20206228not yet assessed
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Loss of De Novo DNA Methylation Causes Expansion of the Mouse Hematopoietic Stem Cell Pool ↗Blood · 2010not yet assessed
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Hematopoietic Stem Cell Properties, Markers, and Therapeutics ↗Elsevier eBooks · 2010not yet assessed
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Contributors ↗Elsevier eBooks · 2010not yet assessed
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Potential of the Side Population in Regenerative Nephrology ↗Elsevier eBooks · 2010not yet assessed
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Mouse hematopoietic stem cell identification and analysis ↗Cytometry Part A · 2008 · PMID 19023891not yet assessed
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Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells ↗PLoS ONE · 2008 · PMID 18523660not yet assessed
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Where new approaches can stem from: Focus on stem cell identification ↗Cytometry Part A · 2008 · PMID 19089995not yet assessed
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The Side Population Contains Functionally Distinct Hematopoietic Stem Cell Subpopulations ↗Blood · 2008not yet assessed
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A Side Order of Stem Cells: The SP Phenotype ↗Stem Cells · 2006 · PMID 16449630not yet assessed
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Kidney Side Population Reveals Multilineage Potential and Renal Functional Capacity but also Cellular Heterogeneity ↗Journal of the American Society of Nephrology · 2006 · PMID 16707564not yet assessed
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Definition and spatial annotation of the dynamic secretome during early kidney development ↗Developmental Dynamics · 2006 · PMID 16538671not yet assessed
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Temporal and spatial transcriptional programs in murine kidney development ↗Physiological Genomics · 2005 · PMID 15998744not yet assessed
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Functional analysis of secreted factors during murine metanephric development using explant cultureMechanisms of Development · 2005not yet assessed
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Molecular and functional characterisation of potential renal stem cells ↗The University of Queensland · 2005not yet assessed
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Identifying the Molecular Phenotype of Renal Progenitor Cells ↗Journal of the American Society of Nephrology · 2004 · PMID 15339983not yet assessed
Full bibliography from OpenAlex; reproducibility verdicts matched by PMID.
Author attribution follows OpenAlex disambiguation, which is imperfect — a researcher's papers can be split across profiles or mixed with a namesake.
Merged across profiles sharing this ORCID where present. See every “Challen G” paper on PubMed ↗