RNA-seq reveals abundant circRNA, lncRNA and mRNA in blood exosomes of normal persons
Exosomes are small membrane vesicles of endocytic origin secreted by most cells, and contain a wealthy cargo of protein and RNA species that can modulate recipient cells’ behaviors and may be used as biomarkers for diagnosis of human diseases. They have been found in blood and are valuable sources for biomarkers due to selective cargo loading and resemblance to their parental cells. The goal of this study is to identify circRNA, lncRNA and mRNA profiles in human blood by high-throughput RNA sequ...
Provenance — who produced it, who reused it
Linked to 13 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Identification of Serum Exosomal hsa-circ-0004771 as a Novel Dia... 2019 · 238 cites
- Regulation of aged skeletal muscle regeneration by circulating e... 2021 · 138 cites
- Tumor-suppressive circRHOBTB3 is excreted out of cells via exoso... 2022 · 106 cites
- Exosomal circGSE1 promotes immune escape of hepatocellular carci... 2022 · 103 cites
9 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.