Epigenetic memory of obesity predisposes to colorectal cancer
Colorectal cancer (CRC) is the third most common cancer worldwide. Obesity is a major risk factor with long-lasting effects on the predisposition to CRC even after weight loss; however, the mechanistic underpinnings remain poorly understood. Using a diet-induced obesity mouse model, we profiled cell-intrinsic alterations in colonic epithelium from young and aged obese mice compared with their age-matched controls, to gain insights into the progression of obesity-associated dysregulations in colo...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
Deep data QC
96/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
High-quality mouse bulk RNA-seq with strong technical metrics. Q30 bases (90.9%) and mean quality (33.7) enable reliable expression profiling; elevated duplication (38.16%) is typical of transcriptome experiments and scored accordingly. Highly reusable for differential expression and transcriptome-wide studies.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0