Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure. We performed gene expression analysis using HG-U133A Affymetrix chips on 135 fresh frozen tissue samples of adenocarcinoma and paired noninvolved lung tissue from current, former and never smokers, with biochemically validated smoking information. ANOVA analysis adjusted for potential confound...
Provenance — who produced it, who reused it
Linked to 153 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Robust enumeration of cell subsets from tissue expression profil... 2015 · 14,074 cites
- YTHDF1 links hypoxia adaptation and non-small cell lung cancer p... 2019 · 374 cites
- MicroRNA-143 (miR-143) Regulates Cancer Glycolysis via Targeting... 2012 · 256 cites
- The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberran... 2014 · 254 cites
- RETRACTED ARTICLE: N6-methyladenosine induced miR-143-3p promote... 2019 · 219 cites
- Interpretation of biological experiments changes with evolution... 2018 · 193 cites
- Large Scale Gene Expression Meta-Analysis Reveals Tissue-Specifi... 2016 · 156 cites
- Predictability of human differential gene expression 2019 · 137 cites
- Overexpression of Lon contributes to survival and aggressive phe... 2013 · 136 cites
- Identifying dysregulated pathways in cancers from pathway intera... 2012 · 126 cites
- Conservation of immune gene signatures in solid tumors and progn... 2016 · 126 cites
- RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proli... 2021 · 120 cites
- High expression levels of pyrimidine metabolic rate–limiting enz... 2020 · 113 cites
- HCP5 is a SMAD3-responsive long non-coding RNA that promotes lun... 2019 · 110 cites
- Differential regulation of the REGγ–proteasome pathway by p53/TG... 2013 · 104 cites
- Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Thr... 2022 · 99 cites
- Loss of Connectivity in Cancer Co-Expression Networks 2014 · 88 cites
- Overexpression of KIF20A confers malignant phenotype of lung ade... 2018 · 88 cites
- TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression... 2020 · 88 cites
- Identification of novel gene expression signature in lung adenoc... 2017 · 86 cites
- Personalized identification of altered pathways in cancer using... 2014 · 85 cites
- USP12 downregulation orchestrates a protumourigenic microenviron... 2021 · 77 cites
- Epithelial tumor suppressor ELF3 is a lineage-specific amplified... 2019 · 71 cites
57 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently