Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements
The imprecision of linking intergenic mutations to target genes has limited molecular understanding of diverse human diseases. Here, we show H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells. Differentiation of naïve T cells to either T helper 17 cells or regulatory T cells create subtype-specific enhancer-promoter interactions, specifically at regions of shared DNA accessibilit...
Provenance — who produced it, who reused it
Linked to 18 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Transcript-indexed ATAC-seq for precision immune profiling 2018 · 161 cites
- Chromatin alternates between A and B compartments at kilobase sc... 2023 · 148 cites
- Time-dependent effect of 1,6-hexanediol on biomolecular condensa... 2021 · 100 cites
- Prioritizing disease and trait causal variants at the TNFAIP3 lo... 2020 · 81 cites
13 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently