hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
Alternative cleavage and polyadenylation (APA) can occur at more than half of all human genes, greatly enhancing the cellular repertoire of mRNA isoforms. As these isoforms can have altered stability, localisation and coding potential, deregulation of APA can disrupt gene expression and this has been linked to many diseases including cancer progression. How APA generates cancer-specific isoform profiles and what their physiological consequences are, however, is largely unclear. Here we use a sub...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- hnRNPC regulates cancer-specific alternative cleavage and polyad... 2019 · 143 cites
Deep data QC
33/100 · FStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Bulk RNA-seq (Homo sapiens, Ion Torrent). Grade F, 33/100. Q30 critically low at 4.4% and mean quality 23.2 (both measured) fail standards for reliable expression quantification. Not recommended for reuse.
The F grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0