CARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis
We investigated the role of PRMT4 in normal and malignant hematopoiesis. We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leukemia cell lines, identifying several mechanisms for the leukemia-specific dependence on PRMT4.
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
Deep data QC
94/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Human bulk RNA-seq. A-grade (94/100) with high base quality (Q30=96.1%) compensating for significant duplication (45.97%, scored 64/100), both measured. Duplication suggests PCR amplification bias affecting specific transcripts; findings should be validated with independent quantification methods. Fetch error prevented metadata retrieval but sequence metrics are fully measured.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0