GSE104686

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Internal N6-methyladenosine (m6A) modification is widespread in messenger RNAs(mRNAs) and catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) andMettl14. To understand the role of m6A in development, we deleted Mettl14 in embryonicneural stem cells (NSCs) in a mouse model. Phenotypically, NSCs lacking Mettl14 displaymarkedly decreased proliferation and premature differentiation, suggesting m6Amodification enhances NSC self-renewal. Decreased NSC pool led to decreased numberlat...

Provenance — who produced it, who reused it

Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.

Standardized, field-standard QC computed by touching the data — every metric states how it was obtained

measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently