GSE104961

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

The discovery that genomes are partitioned into self-interacting modules or topologically associated domains (TADs) has revolutionized our understanding of the multiscale organization of chromatin. TADs are often considered as stable structures over time, however this view contrasts with the structural dynamics needed for DNA to cope rapidly and accurately with cell-specific and developmental programs regulation. Here, we combine super-resolution microscopy with state-of-the-art DNA labeling met...

Provenance — who produced it, who reused it

Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.

Standardized, field-standard QC computed by touching the data — every metric states how it was obtained

No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.

measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently