Transcriptional regulation of adaptive NK and CD8 T cell responses [RNA-Seq]
Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Here we look at transcriptional profiles of NK cells throughout several time points during MCMV infection, ex-vivo cytokine stimulation, and/or deficiency of key transcription factors such as STAT4, STAT1, and Runx1. In addition, we profile parallel time points of MCMV-specific CD8 T cells during infection and memory formation.
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The RNA m6A reader YTHDF2 controls NK cell antitumor and antivir... 2021 · 206 cites
Deep data QC
88/100 · BStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Mouse bulk RNA-seq (HiSeq 2500). Grade-B data (88/100) limited by Q30=84.4% (scored 72/100), below ideal thresholds for isoform detection, measured. Minimal duplication (6.29%) and large depth (4B bases) provide partial compensation; suitable for discovery but not recommended for high-sensitivity variant or isoform calls.
The B grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0