Dynamic remodeling of translation programs drives hepatocyte proliferation during liver regeneration
During liver regeneration, most new hepatocytes arise from pre-existing ones; yet, the underlying mechanisms that drive these cells from quiescence to proliferation remain poorly defined. By using high-resolution transcriptome profiling of polysome fractions from purified hepatocytes isolated from quiescent and toxin-injured adult mouse livers,we uncover the mRNA transcripts regulated during liver regeneration. The translational remodeling modulates protein levels of a set of splicing factors in...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
Deep data QC
86/100 · BStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Bulk RNA-seq (mouse). Grade B: high base quality (Q30=97.2%, base quality=39.7) undermined by severe PCR duplication (68.2%), suggesting library complexity or amplification issues. The long reads (99.5 bp mean) are favorable, but elevated duplication will inflate variance in expression estimates for low-abundance genes. Consider filtering duplicates or using UMI-aware quantitation if available.
The B grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0