The thioredoxin-1 system is essential for fueling DNA synthesis during T cell metabolic reprogramming and proliferation
The thioredoxin-1 (Trx1) system is a key player of the cellular redox balance and a sensor of energy and glucose metabolism. Here we report critical c-Myc-dependent activation of the Trx1 system during glucose-driven T cell expansion during development and immune responses but endogenous Trx1-repression during quiescence. Thioredoxin-reductase-1 (Txnrd1)-deletion in CD4-CD8- thymocytes prevented their expansion, while deletion in CD4+CD8+ thymocytes did not affect further maturation and peripher...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The thioredoxin-1 system is essential for fueling DNA synthesis... 2018 · 129 cites
Deep data QC
69/100 · DStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Marginal-grade mouse bulk-RNA-seq with multiple moderate defects: adapter content 12.33%, Q30=84.3%, and moderate duplication (40.2%). Long read length (151 bp) with cumulative quality issues limits reuse suitability; deep filtering or preprocessing needed.
The D grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0