Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
VCP is an evolutionary conserved ubiquitin-dependent ATPase that mediates the degradation of proteins through the ubiquitin-proteasome pathway. Despite the central role of VCP in the regulation of protein homeostasis, identity and nature of its cellular substrates remain poorly defined. Here, we combined chemical inhibition of VCP and quantitative ubiquitin remnant profiling to assess the effect of VCP inhibition on the ubiquitin-modified proteome and to probe the substrate spectrum of VCP in hu...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Proteomic profiling of VCP substrates links VCP to K6‐linked ubi... 2018 · 152 cites
Deep data QC
79/100 · CStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
NextSeq 500 short-read RNA-seq from human samples with 152M reads and moderate quality metrics (88.7% Q30); typical of NextSeq chemistry trade-offs between depth and base quality—addresses standard transcriptomics questions like differential expression or isoform detection.
The C grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0