The humoral immune system has a key prognostic impact in node-negative breast cancer
Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional prognostic motives we analyzed the gene expression patterns of 200 tumors of patients who were not treated by systemic therapy after surgery using a discovery approach. After performing hierarchical cluster analysis, we identified co-regulated genes related to the biological process of proliferation, steroid hormone receptor expression, as well as B cell an...
Provenance — who produced it, who reused it
Linked to 130 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- clusterProfiler: an R Package for Comparing Biological Themes Am... 2012 · 38,150 cites
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- Cutoff Finder: A Comprehensive and Straightforward Web Applicati... 2012 · 1,270 cites
- Wild-type p53 upregulates an early onset breast cancer-associate... 2018 · 539 cites
- G9a interacts with Snail and is critical for Snail-mediated E-ca... 2012 · 448 cites
- Effective breast cancer combination therapy targeting BACH1 and... 2019 · 413 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer 2012 · 303 cites
- bc-GenExMiner 3.0: new mining module computes breast cancer gene... 2013 · 277 cites
- Opposing Functions of BRD4 Isoforms in Breast Cancer 2020 · 207 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Elp3 links tRNA modification to IRES-dependent translation of LE... 2016 · 180 cites
- Genome-wide profiles of CtBP link metabolism with genome stabili... 2013 · 177 cites
- Changes of N6-methyladenosine modulators promote breast cancer p... 2019 · 168 cites
- Identification of Prognosis-Relevant Subgroups in Patients with... 2013 · 161 cites
- Downregulation of long noncoding RNA MALAT1 induces epithelial-t... 2015 · 151 cites
- Defining super-enhancer landscape in triple-negative breast canc... 2021 · 150 cites
- BreastMark: An Integrated Approach to Mining Publicly Available... 2013 · 143 cites
- HMGA1 promotes metastatic processes in basal-like breast cancer... 2013 · 134 cites
- Hypoxia-inducible factor 1 mediates TAZ expression and nuclear l... 2014 · 116 cites
- Expression profiling of ion channel genes predicts clinical outc... 2013 · 115 cites
- Breast cancer genome and transcriptome integration implicates sp... 2016 · 114 cites
- The RNA binding protein FXR1 is a new driver in the 3q26-29 ampl... 2015 · 101 cites
- The gene expression landscape of breast cancer is shaped by tumo... 2012 · 94 cites
- Mitohormesis Primes Tumor Invasion and Metastasis 2019 · 94 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- Adversarial deconfounding autoencoder for learning robust gene e... 2020 · 87 cites
- The cell cycle regulator 14-3-3σ opposes and reverses cancer met... 2015 · 87 cites
- Systematic Analysis of Gene Expression Alteration and Co-Express... 2018 · 84 cites
- Bioinformatics analysis of the serine and glycine pathway in can... 2014 · 79 cites
- Network and Data Integration for Biomarker Signature Discovery v... 2013 · 77 cites
- Integration of mRNA Expression Profile, Copy Number Alterations,... 2014 · 76 cites
- Cyclin D1 induction of Dicer governs microRNA processing and exp... 2013 · 74 cites
- SPHK1 regulates proliferation and survival responses in triple-n... 2014 · 73 cites
- p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expre... 2015 · 72 cites
45 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.