Gene expression profiling reveals that ERα controls the mitochondrial biogenesis in LysM-Cre targeted cells
Estrogens decrease osteoclast numbers via direct and indirect effects. In trabecular bone, the anti-osteoporotic efficacy of estrogens is mediated via the estrogen receptor α (ERα) present in myeloid lineage cells, but the molecular mechanism mediating these effects remain controversial. In contrast to published findings by others, FasLgld/gld mice which lack functional FasL lost cortical and cancellous bone following OVX indistinguishably from FasL-intact controls. Microarray analysis of osteoc...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
1 further paper cites this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently