Evaluation of PDE5A and PDE9A Inhibition Impacts on Cardiac mRNA Expression in a Mouse Pressure-Overload-Induced Heart Failure Model
Purpose: This study aimed to determine how two drugs, both ultimately activating the same effector kinase, may differentially modulate mRNA expression in a mouse model of cardiac pressure-overload-induced heart failure. Methods: C57Bl/6J mice were subjected to sham or TAC surgeries to induce cardiac pressure-overload and subsequent heart failure. After one week, treatment with either a PDE5A inhibitor (PDE5A-I) or PDE9A inhibitor (PDE9A-I) was initiated and continued for 4 weeks, with cardiac fu...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- YAP Partially Reprograms Chromatin Accessibility to Directly Ind... 2019 · 280 cites
1 further paper cites this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently