Genome-wide analysis of estrogen receptor binding sites
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation,particularly in the case of estrogen-suppre...
Provenance — who produced it, who reused it
Linked to 11 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Target analysis by integration of transcriptome and ChIP-seq dat... 2013 · 582 cites
- Gene expression profiles of inflammatory breast cancer: correlat... 2013 · 130 cites
- Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotox... 2019 · 129 cites
- Estrogen controls the survival of BRCA1-deficient cells via a PI... 2014 · 122 cites
- Estrogen-induced upregulation and 3′-UTR shortening of CDC6 2012 · 107 cites
6 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently