Exosome release is regulated by mTORC1 via a Rab27A-dependent mechanism
Exosomes are small membrane-bound vesicles released into extracellular spaces by many types of cells. These nanovesicles carry proteins, mRNA and miRNA and are involved in cell waste management and intercellular communication. In the present study we show that exosome release, which leads to net loss of cellular membrane and protein content, is negatively regulated by mechanistic target of rapamycin complex 1 (mTORC1). We find that in cells and animal models exosome release is inhibited by susta...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
Deep data QC
67/100 · DStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
miRNA-seq of Homo sapiens via Illumina Genome Analyzer with exceptional quality (97.6% Q30, 0.004% N content) and confirmed GEO UID. This dataset enables human microRNA discovery and quantification across tissues or disease states. The excellent base quality and mature miRNA-appropriate read length (~50 bp) support robust microRNA identification and target validation studies.
The D grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0