Mapping of transcription factor binding sites in mouse embryonic stem cells
Transcription factors and their specific interactions with targets are crucial in specifying gene expression programs. To gain insights into the transcriptional regulatory networks in embryonic stem cells, we use chromatin immunoprecipitation coupled to ultra-high-throughput DNA sequencing (ChIP-seq) to map the locations of thirteen sequence specific transcription factors (Nanog, Oct4, STAT3, Smad1, Sox2, Zfx, c-Myc, n-Myc, Klf4, Esrrb, Tcfcp2l1, E2f1 and CTCF) and two transcription regulators (...
Provenance — who produced it, who reused it
Linked to 73 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Single-cell multi-omics sequencing of mouse early embryos and em... 2017 · 393 cites
- Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embry... 2012 · 393 cites
- Transcription factors orchestrate dynamic interplay between geno... 2018 · 383 cites
- Exit from Pluripotency Is Gated by Intracellular Redistribution... 2013 · 359 cites
- oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representa... 2012 · 301 cites
- A dynamic mode of mitotic bookmarking by transcription factors 2016 · 298 cites
- Distinct Classes of Chromatin Loops Revealed by Deletion of an R... 2019 · 275 cites
- Insights into Nucleosome Organization in Mouse Embryonic Stem Ce... 2016 · 231 cites
- Identification of the missing pluripotency mediator downstream o... 2013 · 224 cites
- Profiling of Pluripotency Factors in Single Cells and Early Embr... 2019 · 209 cites
- Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in E... 2020 · 205 cites
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- Genome-wide analysis identifies a functional association of Tet1... 2013 · 176 cites
- High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcyto... 2013 · 175 cites
- Transcription factor TFCP2L1 patterns cells in the mouse kidney... 2017 · 124 cites
- A strand-specific switch in noncoding transcription switches the... 2014 · 109 cites
- Intragenic Enhancers Attenuate Host Gene Expression 2017 · 100 cites
- Functional cis-regulatory modules encoded by mouse-specific endo... 2017 · 98 cites
- Exploring the Cooccurrence Patterns of Multiple Sets of Genomic... 2013 · 95 cites
- glbase: a framework for combining, analyzing and displaying hete... 2014 · 94 cites
- Distinct transcriptional regulatory modules underlie STAT3’s cel... 2013 · 79 cites
- Enhancer identification in mouse embryonic stem cells using inte... 2012 · 78 cites
- Non-targeted transcription factors motifs are a systemic compone... 2014 · 75 cites
- Phosphorylation of TFCP2L1 by CDK1 is required for stem cell plu... 2019 · 75 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
48 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.