Corpus 1,272 assessed · 1,173 scored · 643 reproduced ≥75 · 168 flagged ·∅ 74.1/100
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GSE115821

GEO first seen 2018

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Organism
Homo sapiens
Samples
37
Type
Expression profiling by high...
Submitted
2018-06-14

Immune checkpoint blockade (ICB) therapy provides remarkable clinical gains, where melanoma is at the forefront of its success. However, only a subset of patients with advanced tumors currently benefit from these therapies, which at times incur considerable side-effects and costs. Constructing such predictors of patient’s response has remained a serious challenge due to the complexity of the immune response and the shortage of large ICB-treated patient cohorts including both omics and response d...

Provenance — who produced it, who reused it

Linked to 25 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.

Deposited / produced by
Zhang GaoTian Tian
Robust prediction of response to immune checkpoint blockade ther... 2018
Reused by

22 further papers cite this accession but reuse could not be confirmed.

Deep data QC

69/100 · D

Standardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured

What this means
claude:haiku

Bulk RNA-seq (human). Grade D quality (69/100) with borderline reusability. Q30 of 81.4% (57/100 score, primary constraint) and elevated duplication at 44.86% (67/100) together suggest PCR bias or over-amplification that will skew expression estimates. Reuse requires careful normalization for batch/duplication effects.

Data type / assay
bulk-RNA-seq
Organism
Homo sapiens
Files available
CSV
Metrics (value · how obtained)
n content pct 0.03 measured
pct q20 bases 87.4 measured
pct q30 bases 81.4 measured
gc content pct 51.9 measured
mean read length 76 measured
mean base quality 32.2 measured
adapter content pct 0.04 measured
duplication rate pct 44.86 measured
supplementary file types CSV reported
How this grade was computed
Weighted mean of 4 scored metric(s) → 69/100

The D grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.

pct q30 bases 81.4 measured ×1 57%
mean base quality 32.2 measured ×0.6 70%
adapter content pct 0.04 measured ×0.4 100%
duplication rate pct 44.86 measured ×0.4 67%

measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0

Scientific quality

Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.

1 studies use it 1 reproduced mean score 100