GSE117193

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance

Clinical expression of core pluripotent stem cell master regulators OCT4, SOX2 and NANOG is associated with treatment resistance and lethal cancers. We have described a novel model to induce the expression of these factors in vitro. We term this culture environment ‘Acquired Pluripotent Stem Cell Environment (APSCE)’ and RNA-seq comparisons were made to culture in conventional serum supplemented ‘Full Media’ (FM) in human prostate (LNCaP, CWR22Rv1) and bladder (RT112) cancer cell lines. Depletio...

Provenance — who produced it, who reused it

Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.

Standardized, field-standard QC computed by touching the data — every metric states how it was obtained

measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently