Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established. We describe here a new map of the transcriptional regulatory circuitry of ES cells that incorporates both protein-coding and miRNA genes, and which is based on high-resolution ChIP-seq data, systematic identification of miRNA promoters, and quantitative sequencing of s...
Provenance — who produced it, who reused it
Linked to 34 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embry... 2012 · 393 cites
- Exit from Pluripotency Is Gated by Intracellular Redistribution... 2013 · 359 cites
- Profiling of Pluripotency Factors in Single Cells and Early Embr... 2019 · 209 cites
- Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in E... 2020 · 205 cites
- Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic St... 2012 · 204 cites
- MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthol... 2012 · 200 cites
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Fa... 2012 · 135 cites
- Intragenic Enhancers Attenuate Host Gene Expression 2017 · 100 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
24 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently