Gene expression changes in the course of normal brain aging are sexually dimorphic
This dataset of cognitively normal controls is a subset of the GSE48350 dataset, which additionally contains microarray data from AD brains. Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain aging emerged, revealing two overarching concepts. First,...
Provenance — who produced it, who reused it
Linked to 22 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Restricted diet delays accelerated ageing and genomic stress in... 2016 · 319 cites
- A novel multi-tissue RNA diagnostic of healthy ageing relates to... 2015 · 248 cites
- Variation among intact tissue samples reveals the core transcrip... 2018 · 209 cites
- Concerted Perturbation Observed in a Hub Network in Alzheimer’s... 2012 · 113 cites
- Glycosylated extracellular vesicles released by glioblastoma cel... 2018 · 102 cites
- Exploring the Transcriptome of Ciliated Cells Using In Silico Di... 2012 · 87 cites
- Weighted Frequent Gene Co-expression Network Mining to Identify... 2012 · 86 cites
14 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently