G-tract RNA removes Polycomb Repressive Complex 2 from genes
Polycomb Repressive Complex 2 (PRC2) maintains repression of genes specific for other cell types but associates with genes ectopically in cancer. How PRC2 is removed from genes is unknown but this knowledge may allow the targeted reversal of deleterious PRC2 recruitment events. We show that G-tract RNA specifically removes PRC2 from genes in human and mouse cells. PRC2 preferentially binds G-tracts within nascent pre-mRNAs, especially within predicted G-quadruplex structures. G-quadruplex RNA ev...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- G-tract RNA removes Polycomb repressive complex 2 from genes 2019 · 115 cites
1 further paper cites this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently