Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Genome-wide maps of chromatin state (H3K4me3, H3K9me3, H3K27me3, H3K36me3, H4K20me3) in pluripotent and lineage-committed cells We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic stem cells, neural progenitor cells and embryonic fibroblasts. We find...
Provenance — who produced it, who reused it
Linked to 33 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- PRC2 binds active promoters and contacts nascent RNAs in embryon... 2013 · 307 cites
- Epigenetic conservation at gene regulatory elements revealed by... 2013 · 246 cites
- Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic St... 2012 · 204 cites
- The Mll2 branch of the COMPASS family regulates bivalent promote... 2013 · 191 cites
- Bivalent Chromatin Marks Developmental Regulatory Genes in the M... 2013 · 179 cites
- Genome-wide analysis identifies a functional association of Tet1... 2013 · 176 cites
- High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcyto... 2013 · 175 cites
- DNA methylation regulates discrimination of enhancers from promo... 2017 · 142 cites
- Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem C... 2015 · 117 cites
- Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Depend... 2017 · 107 cites
- Enhancer identification in mouse embryonic stem cells using inte... 2012 · 78 cites
22 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published ChIP-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0