Age-dependent decline of TET1-mediated DNA hydroxy-methylation impairs myelin regeneration after injury
Adult myelination is recognized as essential for brain function and response to injury and yet, its molecular understanding is mostly inferred from developmental studies. In this study, we identify DNA hydroxy-methylation, an epigenetic mark catalyzed by Ten-Eleven translocation (TET) enzymes, as necessary for adult, but not for developmental, myelin formation. While hydroxy-methylation and high levels of TET1 were detected in young adult mice during myelin regeneration after lysolecithin-induce...
Provenance — who produced it, who reused it
Linked to 2 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
1 further paper cites this accession but reuse could not be confirmed.
Deep data QC
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measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently