Human brain tissues from healthy controls and multiple sclerosis patients
Multiple sclerosis (MS) is characterized by cell proliferation, migration and damage in various cell types in different CNS regions and causes disabilities related to distinct neurological pathways, such as walking, vision and cognition. Here, region-specific transcriptomic approach was used to determine changes in gene expression in five different CNS regions (hippocampus, frontal cortex, internal capsule, corpus callosum, and parietal cortex) in MS.
Provenance — who produced it, who reused it
Linked to 5 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Gene expression in oligodendrocytes during remyelination reveals... 2019 · 166 cites
4 further papers cite this accession but reuse could not be confirmed.
Deep data QC
90/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Homo sapiens bulk RNA-seq. Grade A (90/100) with excellent base quality (96.5% Q30, 39.2 mean BQ). Moderate duplication (55.79%) is the only minor concern and may reflect true biology or PCR bias; overall quality supports robust differential expression and splicing analysis. Highly reusable.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.