miR205 Regulates Mammary Gland Development and Stem Cell Self-renewal through YAP and Wnt signaling
Mammary gland development is fueled by stem cell self-renewal and differentiation. External cues from the microenvironment coupled with internal cues such as post-transcriptional regulation exerted by miRNAs regulate stem cell behavior and stem cell fate. We have identified a miR205 regulatory network required for mammary gland morphogenesis and stem cell maintenance. In the postnatal mammary gland, miR205 is predominantly expressed in the basal/stem cell enriched population. Conditional deletio...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- 3′ Uridylation Confers miRNAs with Non-canonical Target Repertoi... 2019 · 101 cites
Deep data QC
100/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Mouse bulk RNA-seq data from this experiment feature excellent quality metrics (98.1% Q30, 98.8% Q20) with 101 bp reads and minimal adapter contamination (0.47%), enabling reliable genomic mapping and transcript assembly. The read length is sufficient for both de novo and reference-guided transcriptome reconstruction, making it suitable for complex isoform studies and expression profiling.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0