Single-cell multi-omic integration compares and contrasts features of brain cell identity
To flexibly model single-cell datasets, we developed LIGER, an algorithm and software package that delineates shared and dataset-specific features of cell identity. We applied it to four diverse and challenging analyses of human and mouse brain cells, the first two of which include newly generated single-cell transcriptome datasets for mouse and human regions. First, we determined region-specific and sexually dimorphic gene expression in the mouse bed nucleus of the stria terminalis (BNST). Sec...
Provenance — who produced it, who reused it
Linked to 7 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Gene regulation by gonadal hormone receptors underlies brain sex... 2022 · 232 cites
- STAB: a spatio-temporal cell atlas of the human brain 2020 · 71 cites
4 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently