Landscape of intercellular crosstalk in fatty liver disease revealed by single-cell secretome analysis
Cell-cell communications via ligand-receptor signaling are a fundamental feature of complex organs. In addition to hepatocytes, the mammalian liver harbors several distinct cell types, including endothelial cells, hepatic stellate cells (HSC), cholangiocytes, the resident macrophage Kupffer cells, and other immune cells, collectively known as non-parenchymal cells (NPC) 1-5. Paracrine signaling among NPC is important for tissue homeostasis and has been implicated in the pathogenesis of nonalcoho...
Provenance — who produced it, who reused it
Linked to 7 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- A spatial vascular transcriptomic, proteomic, and phosphoproteom... 2021 · 112 cites
- Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects o... 2020 · 79 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
70/100 · CStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The C grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0