Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation
Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a series of microRNAs that induce cardiomyocyte proliferation and stimulate cardiac regeneration after myocardial infarction. Here we investigate the mechanism of action of the top ten most effective of these miRNAs. Analysis of the transcriptional profile of miRNA-treated cardiomyocytes revealed an involvement of the Hippo-YAP pathway...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Common Regulatory Pathways Mediate Activity of MicroRNAs Inducin... 2019 · 111 cites
Deep data QC
95/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Bulk RNA-seq of Rattus norvegicus (Norway rat) via HiSeq 2000 with good base quality (89.6% Q30, 0.056% N content) and confirmed GEO UID. This dataset enables gene expression profiling in a laboratory rodent model for neuroscience, behavioral, and disease research. The substantial read depth and confirmed platform enable reliable transcript quantification across experimental conditions.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0