Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development
Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal epithelial immunity in Caenorhabditis elegans. During nematode development, olrn-1 is required to program the expression of odorant receptors in the AWC olfactory neuron pair. Here, we show that olrn-1 also functions in AWC neurons in the cell non-autonomous suppr...
Provenance — who produced it, who reused it
Linked to 1 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
Deep data QC
97/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Bulk RNA-seq of Caenorhabditis elegans with unavailable platform details (HTTP error), but concerning quality metrics showing high N content (1.85%), lower Q30 (88.5%), and moderate read length (50 bp). This dataset captures nematode transcriptomics but data quality issues require aggressive filtering. Researchers should contact GEO to investigate the cause of the elevated N content and lower quality metrics.
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0