A developmental landscape of 3D-cultured human pre-gastrulation embryos
Knowledge detailing human pre-gastrulation embryonic development including spatial self-organization and cell type ontogeny remains limited by available twodimensional technological platforms that do not recapitulate the in vivo condition. Here, we report a three-dimensional (3D) blastocyst-culture system, which enables human blastocyst development through primitive streak anlage (PSA) formation. These 3D-embryos mimic in vivo developmental landmarks and 3D-architectures, including embryonic dis...
Provenance — who produced it, who reused it
Linked to 17 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Human naive epiblast cells possess unrestricted lineage potentia... 2021 · 346 cites
- Capture of Mouse and Human Stem Cells with Features of Formative... 2020 · 272 cites
- Pluripotent stem cell-derived model of the post-implantation hum... 2023 · 224 cites
- Spatial profiling of early primate gastrulation in utero 2022 · 159 cites
- Amniogenesis occurs in two independent waves in primates 2022 · 101 cites
- Modeling human extraembryonic mesoderm cells using naive pluripo... 2022 · 86 cites
11 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.