Expression data from primary gastric tumors (MSI and MSS) and adjacent normal samples
Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-...
Provenance — who produced it, who reused it
Linked to 104 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Tumor-derived exosomes induce N2 polarization of neutrophils to... 2018 · 334 cites
- The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransfera... 2024 · 260 cites
- Separate enrichment analysis of pathways for up- and downregulat... 2013 · 216 cites
- Long noncoding RNA ZFAS1 promotes gastric cancer cells prolifera... 2016 · 160 cites
- Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti... 2020 · 148 cites
- Identification of hub genes and potential molecular mechanisms i... 2018 · 135 cites
- <scp>FAM</scp>83 family oncogenes are broadly involved in human... 2017 · 128 cites
- HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferat... 2019 · 124 cites
- Targeting IRF3 as a YAP agonist therapy against gastric cancer 2018 · 120 cites
- PreMSIm: An R package for predicting microsatellite instability... 2020 · 114 cites
- SERPINE1 Overexpression Promotes Malignant Progression and Poor... 2022 · 109 cites
- DLAT subunit of the pyruvate dehydrogenase complex is upregulate... 2015 · 106 cites
- MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-... 2019 · 98 cites
- Loss of Connectivity in Cancer Co-Expression Networks 2014 · 88 cites
- Removing batch effects for prediction problems with frozen surro... 2014 · 88 cites
- A distinct p53 target gene set predicts for response to the sele... 2015 · 87 cites
- Molecular Profiling of Multiple Human Cancers Defines an Inflamm... 2013 · 86 cites
- An integrative analysis reveals functional targets of GATA6 tran... 2013 · 81 cites
- CrossNorm: a novel normalization strategy for microarray data in... 2016 · 76 cites
- A Systems Approach to Predict Oncometabolites via Context-Specif... 2014 · 76 cites
60 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently