Single-nucleus RNA-seq in the post-mortem brain in major depressive disorder
We performed high-throughput snRNA-seq using the 10X Genomics Chromium platform on archived post-mortem dorsolateral prefrontal cortex (BA9) tissue in MDD subjects who died by suicide and in control subjects to identify cell-type specific differentially expressed genes.
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Confronting false discoveries in single-cell differential expres... 2021 · 980 cites
- Spatially informed clustering, integration, and deconvolution of... 2023 · 586 cites
- Learning interpretable cellular and gene signature embeddings fr... 2021 · 94 cites
- CellDART: cell type inference by domain adaptation of single-cel... 2022 · 82 cites
12 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently