Gene expression profiling of CEBPA double and single mutant and CEBPA wild type AML.
Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5-14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry two mutations (CEBPAdouble-mut), usually biallelic, while single heterozygous mutations (CEBPAsingle-mut) are less frequently seen. Using denaturing high performance liquid chromatography and nucleotide sequencing we identified among a cohort of 598 newly diagnosed AMLs a subset...
Provenance — who produced it, who reused it
Linked to 35 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrating Proteomics and Transcriptomics for Systematic Combin... 2017 · 346 cites
- Curcumin targets multiple enzymes involved in the ROS metabolic... 2018 · 205 cites
- miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tum... 2012 · 167 cites
- Targeting MTHFD2 in acute myeloid leukemia 2016 · 165 cites
- PRMT1-mediated FLT3 arginine methylation promotes maintenance of... 2019 · 93 cites
- Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leu... 2019 · 90 cites
- Salt-inducible kinase inhibition suppresses acute myeloid leukem... 2019 · 82 cites
28 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently