Transcriptional response to SARS-CoV-2 infection
Viral pandemics pose an imminent threat to humanity. The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, requires the urgent development of anti-viral therapies. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here, we offer an in-depth analysis of the host response to SARS-CoV-2 as it compares to other respiratory infections. Cell and animal models of SARS-CoV-2 infections, in addition to tr...
Provenance — who produced it, who reused it
Linked to 124 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- NCBI GEO: archive for gene expression and epigenomics data sets:... 2023 · 404 cites
- Integrated intra‐ and intercellular signaling knowledge for mult... 2021 · 370 cites
- Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome... 2021 · 300 cites
- SARS-CoV-2-mediated dysregulation of metabolism and autophagy un... 2021 · 293 cites
- Induction of alarmin S100A8/A9 mediates activation of aberrant n... 2020 · 266 cites
- A comprehensive SARS-CoV-2–human protein–protein interactome rev... 2022 · 199 cites
- A network medicine approach to investigation and population-base... 2020 · 185 cites
- SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyr... 2022 · 176 cites
- Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, S... 2020 · 169 cites
- Inferring microenvironmental regulation of gene expression from... 2020 · 132 cites
- Integrative analyses of SARS-CoV-2 genomes from different geogra... 2020 · 119 cites
- Connecting omics signatures and revealing biological mechanisms... 2022 · 115 cites
- COVID19 Disease Map, a computational knowledge repository of vir... 2021 · 111 cites
- Role of miR-2392 in driving SARS-CoV-2 infection 2021 · 97 cites
- Bioinformatics and system biology approach to identify the influ... 2021 · 96 cites
- High affinity of host human microRNAs to SARS-CoV-2 genome: An i... 2020 · 83 cites
- Upregulation of oxidative stress gene markers during SARS-COV-2... 2021 · 82 cites
- Host metabolic reprogramming in response to SARS-CoV-2 infection... 2021 · 76 cites
- SARS-CoV-2 infection initiates interleukin-17-enriched transcrip... 2021 · 71 cites
61 further papers cite this accession but reuse could not be confirmed.
Deep data QC
95/100 · AStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The A grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0