Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer
Purpose: The JBR.10 trial demonstrated benefit from adjuvant cisplatin/vinorelbine (ACT) in early-stage non-small-cell lung cancer (NSCLC). We hypothesized that expression profiling may identify stage-independent subgroups who might benefit from ACT. Patients and Methods: Gene expression profiling was conducted on mRNA from 133 frozen JBR.10 tumor samples (62 observation [OBS], 71 ACT). The minimum gene set that was selected for the greatest separation of good and poor prognosis patient subgrou...
Provenance — who produced it, who reused it
Linked to 47 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- SurvExpress: An Online Biomarker Validation Tool and Database fo... 2013 · 716 cites
- Shortening of 3′UTRs Correlates with Poor Prognosis in Breast an... 2012 · 123 cites
- Lung tumor NF-κB signaling promotes T cell–mediated immune surve... 2013 · 104 cites
- DNA Repair Pathway Gene Expression Score Correlates with Repair... 2014 · 100 cites
- Sortilin limits EGFR signaling by promoting its internalization... 2017 · 84 cites
- FBXO11 promotes ubiquitination of the Snail family of transcript... 2015 · 83 cites
- <scp>SETDB1</scp> accelerates tumourigenesis by regulating the <... 2014 · 78 cites
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeo... 2018 · 78 cites
- Targeting lactate dehydrogenase a improves radiotherapy efficacy... 2021 · 75 cites
38 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently