Genetic control of human brain transcript expression in Alzheimer’s disease.
We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We now have analyzed additional samples with a confirmed pathologic diagnosis of late onset Alzheimer's disease (LOAD, final n=187 controls, 176 cases). Nine percent of the cortical transcripts we analyzed had expression profiles correlated with their genotypes in the combined cohort and approximately 5% of transcripts had SNP-transcript relationshi...
Provenance — who produced it, who reused it
Linked to 35 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Rare coding variants in the phospholipase D3 gene confer risk fo... 2013 · 476 cites
- Sphingolipid Metabolic Pathway: An Overview of Major Roles Playe... 2013 · 193 cites
- Dissection of Regulatory Networks that Are Altered in Disease vi... 2013 · 182 cites
- A second X chromosome contributes to resilience in a mouse model... 2020 · 181 cites
- Concerted Perturbation Observed in a Hub Network in Alzheimer’s... 2012 · 113 cites
- Polygenic regression uncovers trait-relevant cellular contexts t... 2023 · 94 cites
- Genomic convergence and network analysis approach to identify ca... 2014 · 90 cites
- Exploring the Transcriptome of Ciliated Cells Using In Silico Di... 2012 · 87 cites
- Integrative genomics approach identifies conserved transcriptomi... 2020 · 83 cites
26 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently