Systems biological assessment of immunity to severe and mild COVID-19 infections
CITE-seq of 7 patients with COVID-19 and 5 healthy controls
Provenance — who produced it, who reused it
Linked to 6 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- B cell-specific XIST complex enforces X-inactivation and restrai... 2021 · 222 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
75/100 · CStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
Human RNA-seq with 91 bp reads at 90.2% Q20 and 78.1% Q30 exhibits declining base quality across the read, particularly pronounced in later cycles. The 47.6% GC and mean quality 34.5 support basic transcript counting; however, the low Q30 percentage warrants conservative mapping parameters and post-alignment quality filtering to avoid accumulating substitution errors.
The C grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.