Abundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA expression and microRNA (miRNA) expression in four distinct human brain regions. We show that brain tissues may be readily distinguished based on methylation status or expression profile. We find an...
Provenance — who produced it, who reused it
Linked to 38 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Gene expression elucidates functional impact of polygenic risk f... 2016 · 1,216 cites
- An epigenetic clock analysis of race/ethnicity, sex, and coronar... 2016 · 788 cites
- Aging effects on DNA methylation modules in human brain and bloo... 2012 · 678 cites
- A cell epigenotype specific model for the correction of brain ce... 2013 · 418 cites
- A Role for Noncoding Variation in Schizophrenia 2014 · 271 cites
- Methylation quantitative trait loci (meQTLs) are consistently de... 2014 · 261 cites
- Regulation of lifespan by neural excitation and REST 2019 · 247 cites
- Genome-wide DNA methylation profiling in the superior temporal g... 2016 · 213 cites
- Convergent genetic and expression data implicate immunity in Alz... 2014 · 207 cites
- The cerebellum ages slowly according to the epigenetic clock 2015 · 198 cites
- Identification and Replication of a Combined Epigenetic and Gene... 2014 · 195 cites
- Many obesity-associated SNPs strongly associate with DNA methyla... 2015 · 193 cites
- Global population-specific variation in miRNA associated with ca... 2014 · 137 cites
- Genetic architecture of epigenetic and neuronal ageing rates in... 2017 · 134 cites
- Identification and Analysis of Human Sex-Biased MicroRNAs 2018 · 125 cites
- The transcription factor POU3F2 regulates a gene coexpression ne... 2018 · 115 cites
- Correlation between <scp>DNA</scp> methylation and gene expressi... 2014 · 110 cites
- Multilocus loss of DNA methylation in individuals with mutations... 2013 · 107 cites
- MeDeCom: discovery and quantification of latent components of he... 2017 · 105 cites
- An integrative network algorithm identifies age-associated diffe... 2013 · 92 cites
- Common inversion polymorphism at 17q21.31 affects expression of... 2012 · 91 cites
- Exploring the Transcriptome of Ciliated Cells Using In Silico Di... 2012 · 87 cites
16 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently