Intrinsic Gene Expression Profiles of Gliomas are a Better Predictor of Survival than Histology
Histological classification of gliomas guides treatment decisions. Because of the high interobserver variability, we aimed to improve classification by performing gene expression profiling on a large cohort of glioma samples of all histological subtypes and grades. The seven identified intrinsic molecular subtypes are different from histological subgroups and correlate better to patient survival. Our data indicate that distinct molecular subgroups clearly benefit from treatment. Specific genetic...
Provenance — who produced it, who reused it
Linked to 155 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- clusterProfiler 4.0: A universal enrichment tool for interpretin... 2021 · 12,686 cites
- Sex differences in GBM revealed by analysis of patient imaging,... 2019 · 360 cites
- Long Non-Coding RNA H19 Promotes Glioma Cell Invasion by Derivin... 2014 · 288 cites
- Identification of thioridazine, an antipsychotic drug, as an ant... 2015 · 148 cites
- Causal Mechanistic Regulatory Network for Glioblastoma Deciphere... 2016 · 146 cites
- Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastom... 2013 · 130 cites
- Integrated multi-omics analysis of oligodendroglial tumours iden... 2016 · 113 cites
- Characterization of an endoplasmic reticulum stress‐related sign... 2021 · 102 cites
- A glioma classification scheme based on coexpression modules of... 2014 · 96 cites
- miR-129-5p targets Wnt5a to block PKC/ERK/NF-κB and JNK pathways... 2018 · 96 cites
- MOB2 suppresses GBM cell migration and invasion via regulation o... 2020 · 96 cites
- Targeting the SMO oncogene by miR-326 inhibits glioma biological... 2014 · 95 cites
- BIRC3 is a novel driver of therapeutic resistance in Glioblastom... 2016 · 90 cites
- Identification of the Role and Clinical Prognostic Value of Targ... 2021 · 79 cites
- Immune heterogeneity and clinicopathologic characterization of I... 2018 · 77 cites
- Comparative Analysis of Matrix Metalloproteinase Family Members... 2016 · 74 cites
- Identification of PIEZO1 as a potential prognostic marker in gli... 2020 · 72 cites
63 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.