A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer
Loss of SMAD4 is associated with worse outcomes for colorectal cancer patients. We used gene ontology and data driven approach to identify a SMAD4-modulated profile and test its association with patient outcome. Using a discovery dataset of 250 colorectal cancer patients, we analyzed expression of BMP/Wnt target genes for association with SMAD4 expression. Promoters of the BMP/Wnt genes were interrogated for SMAD-binding elements. 15 genes were implicated and three tested for modulation by SMAD4...
Provenance — who produced it, who reused it
Linked to 20 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Machine learning-based integration develops an immune-derived ln... 2022 · 914 cites
- Integrative analysis from multi-center studies identities a cons... 2021 · 213 cites
18 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.