Metastasis Gene Expression Profile Predicts Recurrence and Death in Colon Cancer Patients (Moffitt Samples)
Background and Aims: Staging inadequately predicts metastatic risk in colon cancer patients. We used a gene expression profile derived from invasive murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify colon cancer patients at risk for recurrence in a phase I, exploratory biomarker study. Methods: 55 colorectal cancer patients from Vanderbilt Medical Center (VMC) were used as the training dataset and 177 patients from the Moffitt Cancer Center we...
Provenance — who produced it, who reused it
Linked to 227 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The consensus molecular subtypes of colorectal cancer 2015 · 5,246 cites
- Gene Expression Classification of Colon Cancer into Molecular Su... 2013 · 1,541 cites
- Machine learning-based integration develops an immune-derived ln... 2022 · 914 cites
- FXR Regulates Intestinal Cancer Stem Cell Proliferation 2019 · 461 cites
- Upregulated METTL3 promotes metastasis of colorectal Cancer via... 2019 · 408 cites
- Contribution of serine, folate and glycine metabolism to the ATP... 2013 · 265 cites
- Subtypes of primary colorectal tumors correlate with response to... 2012 · 257 cites
- Role of pyruvate kinase M2 in transcriptional regulation leading... 2014 · 239 cites
- DeepCC: a novel deep learning-based framework for cancer molecul... 2019 · 234 cites
- Integrative analysis from multi-center studies identities a cons... 2021 · 213 cites
- Refining colorectal cancer classification and clinical stratific... 2022 · 207 cites
- Integrated single-cell and bulk RNA sequencing analysis identifi... 2021 · 167 cites
- The long non-coding RNA CYTOR drives colorectal cancer progressi... 2018 · 162 cites
- A long non-coding RNA signature to improve prognosis prediction... 2014 · 159 cites
- TAZ Expression as a Prognostic Indicator in Colorectal Cancer 2013 · 157 cites
- Identification of pyroptosis-related subtypes, the development o... 2021 · 150 cites
- <i>miR-23a</i> Promotes the Transition from Indolent to Invasive... 2012 · 137 cites
- Nuclear Factor of Activated T-cell Activity Is Associated with M... 2014 · 129 cites
- Metastatic Colorectal Cancer Rewrites Metabolic Program Through... 2019 · 118 cites
- FBXO22 degrades nuclear PTEN to promote tumorigenesis 2020 · 112 cites
- p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2... 2013 · 108 cites
- MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and f... 2020 · 105 cites
- AKT-dependent NOTCH3 activation drives tumor progression in a mo... 2020 · 104 cites
- A multi-dimensional approach to unravel the intricacies of lacty... 2024 · 101 cites
- EMT transcription factor ZEB1 alters the epigenetic landscape of... 2020 · 97 cites
- FSTL1 interacts with VIM and promotes colorectal cancer metastas... 2018 · 96 cites
- Personalized identification of altered pathways in cancer using... 2014 · 85 cites
- TRIB2 functions as novel oncogene in colorectal cancer by blocki... 2018 · 85 cites
- An integrative analysis reveals functional targets of GATA6 tran... 2013 · 81 cites
- KIF20A promotes cellular malignant behavior and enhances resista... 2019 · 80 cites
50 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently