Molecular profiling of ERBB2-amplified breast cancers
15-25% of breast cancers (BC) show ERBB2-amplification and overexpression of the encoded ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better knowledge of these BCs may help understand their behavior and design new therapeutic strategies. In this study, we defined the high resolution genome and gene expression profiles of 54 ERBB2-amplified BCs using 244K oligonucleotide array-comparative genomic hybridization and whole-genome...
Provenance — who produced it, who reused it
Linked to 38 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- LINC02273 drives breast cancer metastasis by epigenetically incr... 2019 · 222 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Actin stress fiber organization promotes cell stiffening and pro... 2017 · 182 cites
- Changes of N6-methyladenosine modulators promote breast cancer p... 2019 · 168 cites
- Downregulation of long noncoding RNA MALAT1 induces epithelial-t... 2015 · 151 cites
- BreastMark: An Integrated Approach to Mining Publicly Available... 2013 · 143 cites
- Cross-species oncogenic signatures of breast cancer in canine ma... 2020 · 115 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- Decorin-mediated suppression of tumorigenesis, invasion, and met... 2021 · 80 cites
28 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently