Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed c...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- HiTC: exploration of high-throughput ‘C’ experiments 2012 · 228 cites
- Three-Dimensional Genome Architecture Influences Partner Selecti... 2012 · 136 cites
- 3D chromatin conformation correlates with replication timing and... 2012 · 95 cites
- HSA: integrating multi-track Hi-C data for genome-scale reconstr... 2016 · 81 cites
- Replication Fork Polarity Gradients Revealed by Megabase-Sized U... 2012 · 75 cites
11 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently