Phenotypic and Molecular Characterization of the Claudin-low Intrinsic Subtype of Breast Cancer
In breast cancer, gene expression analyses have defined five tumor subtypes, each of which has unique biologic and prognostic features. Here, we characterize the recently identified claudin-low tumor subtype as showing low to absent expression of luminal differentiation markers, high enrichment for epithelial-to-mesenchymal transition markers, immune response genes, and cancer stem cell–like features. Clinically, most claudin-low tumors are poorprognosis estrogen receptor–negative, progesterone...
Provenance — who produced it, who reused it
Linked to 29 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Intrinsic subtypes of high-grade bladder cancer reflect the hall... 2014 · 888 cites
- Prognostic Significance of Progesterone Receptor–Positive Tumor... 2012 · 589 cites
- ZEB1 turns into a transcriptional activator by interacting with... 2016 · 298 cites
- Interactions between immunity, proliferation and molecular subty... 2013 · 197 cites
- Genome-wide profiles of CtBP link metabolism with genome stabili... 2013 · 177 cites
- A network module-based method for identifying cancer prognostic... 2012 · 165 cites
- Age-Specific Changes in Intrinsic Breast Cancer Subtypes: A Focu... 2014 · 162 cites
- Genome‐wide cooperation of EMT transcription factor ZEB1 with YA... 2020 · 162 cites
- Treg depletion potentiates checkpoint inhibition in claudin-low... 2017 · 142 cites
- JMJD6 is a driver of cellular proliferation and motility and a m... 2012 · 120 cites
- Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 m... 2015 · 116 cites
- Identification of a multi-cancer gene expression biomarker for c... 2015 · 107 cites
- SHOX2 Is a Direct miR-375 Target and a Novel Epithelial-to-Mesen... 2014 · 93 cites
- Race-associated biological differences among Luminal A breast tu... 2015 · 72 cites
15 further papers cite this accession but reuse could not be confirmed.
Deep data QC
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measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently