Expression data for early stage NSCLC
We identified a tumor signature of 5 genes that aggregates the 156 tumor and normal samples into the expected groups. We also identified a histology signature of 75 genes, which classifies the samples in the major histological subtypes of NSCLC. A prognostic signature of 17 genes showed the best association with post-surgery survival time. The performance of the signatures was validated using a patient cohort of similar size
Provenance — who produced it, who reused it
Linked to 212 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- SurvExpress: An Online Biomarker Validation Tool and Database fo... 2013 · 716 cites
- Ectopic Activation of Germline and Placental Genes Identifies Ag... 2013 · 619 cites
- Contribution of serine, folate and glycine metabolism to the ATP... 2013 · 265 cites
- CD73/NT5E is a target of miR-30a-5p and plays an important role... 2017 · 198 cites
- Interpretation of biological experiments changes with evolution... 2018 · 193 cites
- Overall survival prediction of non-small cell lung cancer by int... 2020 · 192 cites
- Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KL... 2016 · 186 cites
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- A new normalization for Nanostring nCounter gene expression data 2019 · 144 cites
- DTL promotes cancer progression by PDCD4 ubiquitin-dependent deg... 2019 · 143 cites
- Predictability of human differential gene expression 2019 · 137 cites
- m5C RNA Methylation Regulators Predict Prognosis and Regulate th... 2021 · 134 cites
- <scp>FAM</scp>83 family oncogenes are broadly involved in human... 2017 · 128 cites
- Conservation of immune gene signatures in solid tumors and progn... 2016 · 126 cites
- Profiling cancer testis antigens in non–small-cell lung cancer 2016 · 124 cites
- High expression levels of pyrimidine metabolic rate–limiting enz... 2020 · 113 cites
- Long noncoding RNA PCAT6 functions as an oncogene by binding to... 2018 · 111 cites
- HCP5 is a SMAD3-responsive long non-coding RNA that promotes lun... 2019 · 110 cites
- lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, mig... 2022 · 108 cites
- Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Prolif... 2012 · 108 cites
- Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Thr... 2022 · 99 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- Identification of an eight-gene prognostic signature for lung ad... 2018 · 91 cites
- Clinical roles of the aberrantly expressed lncRNAs in lung squam... 2017 · 90 cites
- Inhibition of glutamate oxaloacetate transaminase 1 in cancer ce... 2018 · 88 cites
- ROCK1 promotes migration and invasion of non‑small‑cell lung can... 2019 · 88 cites
- Exploring the Transcriptome of Ciliated Cells Using In Silico Di... 2012 · 87 cites
- A large cohort study identifying a novel prognosis prediction mo... 2019 · 86 cites
- Molecular Profiling of Multiple Human Cancers Defines an Inflamm... 2013 · 86 cites
- Personalized identification of altered pathways in cancer using... 2014 · 85 cites
- Sortilin limits EGFR signaling by promoting its internalization... 2017 · 84 cites
- Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis... 2019 · 84 cites
- FBXO11 promotes ubiquitination of the Snail family of transcript... 2015 · 83 cites
- Ranking metrics in gene set enrichment analysis: do they matter? 2017 · 80 cites
- Bioinformatics analysis of the serine and glycine pathway in can... 2014 · 79 cites
- p63 regulates glutaminase 2 expression 2013 · 78 cites
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeo... 2018 · 78 cites
- Targeting lactate dehydrogenase a improves radiotherapy efficacy... 2021 · 75 cites
- Identification of Key Genes Related to Lung Squamous Cell Carcin... 2020 · 71 cites
- Epithelial tumor suppressor ELF3 is a lineage-specific amplified... 2019 · 71 cites
40 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.